Wnt5a involved in regulation of the biological behavior of hepatocellular carcinoma.

CONCLUSION: Overexpression of Wnt5a in Huh7 cells was associated with decrease of cell proliferation and migration. Wnt5a may act as a tumor-suppressor gene in HCC, which works through the non-canonical Wnt signaling pathway by binding to the Ror2 and E-cadherin receptor.
PMID: 24696716 [PubMed - in process]

Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Bi L, Liu X, Wang C, Cao Y, Mao R, Li P, Geng M Tags: Int J Clin Exp Pathol Source Type: research