Zebrafish for modeling skin disorders.

Zebrafish for modeling skin disorders.
Dermatol Online J. 2016;22(8)
Authors: Cline A, Feldman SR
Abstract
The experimental advantages of zebrafish make this model system highly amenable to the field of dermatology. Zebrafish skin development is similar to humans and its genome is ~70% orthologous to the human genome. Its external developmental process allows for genetic manipulation and analysis of embryogenesis within a short time frame with all important internal organs and skin compartments formed within 6 days. Zebrafish models of cutaneous human diseases offer insight into pathogenesis and a unique platform for testing of potential therapies. This review details the specific advantages of zebrafish and highlights its use in dermatological research.
PMID: 27617951 [PubMed - as supplied by publisher]

Source: Dermatol Online J - September 13, 2016 Category: Dermatology Authors: Cline A, Feldman SR Tags: Dermatol Online J Source Type: research