Is Forgetfulness A Precursor of Alzheimer ’ s?

Credit: Thinkstock  Millions of aging boomers wonder if their memory lapses are from normal aging, or a sign that they are developing Alzheimer’s. There’s some basis for the worry. According to the Alzheimer’s Association, more than 5 million people in the U.S. are living with it. One in three seniors will die with Alzheimer’s or another type of dementia.  While these statistics are scary, you shouldn't let...
Source: Carol Bradley Bursack's SharePosts - Category: Geriatrics Authors: Source Type: blogs

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Publication date: 2019Source: International Review of Neurobiology, Volume 145Author(s): Benedict C. AlbensiAbstractAlzheimer's disease (AD), the most common form of dementia, is thought to be associated with multiple factors, where the greatest risk factor is aging. Several traditional views attribute the cause of AD to genetic heritability, reduced synthesis of the neurotransmitter acetylcholine, the accumulation of a toxic protein known as amyloid β (Aβ) peptide, and/or neurofibrillary tangles of hyperphosphorylated tau-protein, which affect microtubule stability. However, with several recent clinical trial fa...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
(IOS Press) A study conducted by Marc Teichmann and Carole Azuar at the Brain and Spine Institute in Paris (France) and at the Piti é -Salp ê tri è re Hospital shows a particularly marked impairment of moral emotions in patients with frontotemporal dementia (FTD). The results, published in the Journal of Alzheimer'sDisease, open a new approach for early, sensitive and specific diagnosis of FTD.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSION: In conclusion, among clinically normal older adults derived from this population-based study, total burden of NPS was associated with longitudinal cognitive decline. These results add to the evidence that NPS are risk factors for or clinical indicators of preclinical dementia syndrome. Our study was an exploratory study and we did not control for multiple comparisons. PMID: 31186157 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Little attention has been paid to neurotoxicants on the risk of dementia. Exposure to known neurotoxicants such as polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is suspected to have adver...
Source: Environmental Health - Category: Environmental Health Authors: Tags: Research Source Type: research
Tau is a microtubule-associated protein involved in the regulation of axonal microtubules in neurons. In pathological conditions, it forms fibrils that are molecular hallmarks of neurological disorders known as tauopathies. In the last 2 years, cryo-EM has given unprecedented high-resolution views of Tau in both physiological and pathological conditions. We review here these new findings and put them into the context of the knowledge about Tau before this structural breakthrough. The first structures of Tau fibrils, a molecular hallmark of Alzheimer's disease (AD), were based on fibrils from the brain of an individual with...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: JBC Reviews Source Type: research
Give us more cash for research now, Alzheimer ’s charity urges government Related items fromOnMedica Patients at end of life see few specialists Elderly failed by broken care system UK to be 'the world ’s most dementia friendly society’ Numbers detained for their own safety - highest on record Integrated personal commissioning pilots revealed
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractNon-Alzheimer ’s dementias constitute 30% of all dementias and present with major cognitive and behavioral disturbances. Cholinesterase inhibitors improve memory by increasing brain acetylcholine levels and are approved symptomatic therapies for Alzheimer’s disease (AD). They have also been investigated in ot her types of dementias with potential cholinergic dysfunction. There is compelling evidence for a profound cholinergic deficit in Lewy Body dementia (LBD) and Parkinson’s disease dementia (PDD), even to a greater extent than AD. However, this deficit is difficult to objectivize in vascular de...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
Publication date: Available online 13 June 2019Source: Life SciencesAuthor(s): Forough Chakari-Khiavi, Sanam Dolati, Aref Chakari-Khiavi, Hossein Abbaszadeh, Leili Aghebati-Maleki, Tannaz Pourlak, Amir Mehdizadeh, Mehdi YousefiAbstractAlzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches with no long-term cure, cell therapy can be considered as a capable approach...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Zulfiqar S, Garg P, Nieweg K Abstract Historically considered accessory cells to neurons, there is an increasing interest in the role of astrocytes in normal and pathological conditions. Astrocytes are involved in neurotransmitter recycling, antioxidant supply, ion buffering and neuroinflammation i.e. a lot of the same pathways that go astray in Alzheimer's Disease (AD). AD remains the leading cause of dementia in the elderly, one for which there is still no cure. Efforts in AD drug development have largely focused on treating neuronal pathologies that appear relatively late in the disease. The neuroenerge...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Conclusion: The developed assay holds tremendous clinical potential for early diagnosis of AD and monitoring of its progression.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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