Researchers identify new therapeutic target for cancer

A protein that may be an unexplored target to develop new cancer therapies has been identified by researchers. The protein, known as kinase suppressor of Ras, or KSR, is a pseudoenzyme that plays a critical role in the transmission of signals in the cell determining whether cells grow, divide, or die.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 19 July 2018Source: Cancer CellAuthor(s): Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Dan Li, Ruiting Lin, Gina N. Alesi, Xu Wang, Hee-Bum Kang, Lina Song, Dongsheng Wang, Guojing Zhang, Jun Fan, Titus J. Boggon, Lu Zhou, Jeanne Kowalski, Cheng-Kui Qu, Conor E. Steuer, Georgia Z. Chen, Nabil F. Saba, Lawrence H. BoiseSummaryPlatinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we identified microtubule-associated serine/threonine kinase 1 (MAST1) as a main driver of cisplatin resistance in human ca...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Authors: Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL Abstract Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in recent decades and compounds of fungal origin provide a vast reservoir of potential innovational drugs. Here, on example of four mushrooms common for use in Asian and Far East...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
The functionality of the tumor suppressor p53 is altered in more than 50% of human cancers, and many individuals with cancer exhibit amyloid-like buildups of aggregated p53. An understanding of what triggers the pathogenic amyloid conversion of p53 is required for the further development of cancer therapies. Here, perturbation of the p53 core domain (p53C) with subdenaturing concentrations of guanidine hydrochloride and high hydrostatic pressure revealed native-like molten globule (MG) states, a subset of which were highly prone to amyloidogenic aggregation. We found that MG conformers of p53C, probably representing popula...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Protein Structure and Folding Source Type: research
Cancer patients who receive complementary therapies are more likely to shun proven treatments, a study finds.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Amr Ahmed El-Arabey, Salama Abdu Salama, Adel Rashad Abd-AllahAbstractIn 2015, more than 1.6 million new cancer cases with 589,430 deaths were estimated over worldwide. Cancer is a complex disease with abnormal cell growth control which is hallmarked by chromosome misalignment and consequently genomic instability. Mitosis is a well-known target for chemotherapy as taxol and colchicines inhibit tumor cell division by inhibiting mitotic spindle plasticity. Accumulating evidence has revealed that the Centromere-associated protein E (CENP-E) is expr...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Mohammad Rasheduzzaman, Jae-Kyo Jeong, Sang-Youel ParkAbstractAimsTRAIL is a promising anticancer agent that has the potential to sensitize a wide variety of cancer or transformed cells by inducing apoptosis. However, resistance to TRAIL is a growing concern. Current manuscript aimed to employing combination treatment to investigate resveratrol induced TRAIL sensitization in NSCLC.MethodA549 and HCC-15 cells were used in experimental design. Cell viability was determined by morphological image, crystal violet staining and MTT assay. Apoptosis wa...
Source: Life Sciences - Category: Biology Source Type: research
People diagnosed with cancer have a multitude of treatment options, many of which are standard therapies that have been well-studied to improve their chances of surviving their disease or avoiding recurrence. But people are increasingly also folding in complementary medicine approaches — which include nutrients, herbal remedies and other so-called natural supplements — with their cancer treatment regimes. While these are not nearly as well-studied as conventional therapies like surgery, radiation and chemotherapy, many people rely on them because they believe they can improve their chances of surviving their ca...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime Source Type: news
Publication date: Available online 7 July 2018Source: Chemical Engineering JournalAuthor(s): Na Niu, Zhe Zhang, Xi Gao, Zhijun Chen, Shujun Li, Jian LiAbstractPhotodynamic therapy (PDT) shows great potential in anti-cancer therapy. The efficiency of PDT is greatly limited by the hypoxia environment in tumors. However, current methods developed to conquer this problem did not accurately produce oxygen for PDT of a certain amount and in a certain position, which could bring a potential risk to normal cells and tissues. Here, upconverting nanoparticles (UCNPs) and gold oxide (Au2O3) were integrated to prepare an efficient, se...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
The Department of Veterans Affairs and IBM Watson Health have announced a one-year extension to an ongoing public-private partnership applying the AI company ’s technology to genomic data for cancer therapy.
Source: mobihealthnews - Category: Information Technology Source Type: news
(JAMA Network) The use of complementary medicine by patients with four common cancers (breast, prostate, lung or colorectal) was associated with refusal of conventional cancer treatment and with a greater risk of death, although the difference in survival may be alleviated by adherence to all recommended conventional cancer therapies.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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