Morroniside promotes angiogenesis and further improves microvascular circulation after focal cerebral ischemia/reperfusion.

Morroniside promotes angiogenesis and further improves microvascular circulation after focal cerebral ischemia/reperfusion.
Brain Res Bull. 2016 Sep 7;
Authors: Liu T, Xiang B, Guo D, Sun F, Wei R, Zhang G, Ai H, Tian X, Zhu Z, Zheng W, Wang Y, Wang W
Abstract
Preservation of cerebral microvascular functional integrity is crucial for protecting and repairing the brain after stroke. Our previous study demonstrated that morroniside promoted angiogenesis 7days after stroke. The current study aimed to further evaluate the long-term effects of morroniside on angiogenesis and to examine whether angiogenesis induced by morroniside could improve blood flow velocity. Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO), and morroniside was then administered once per day at a dose of 270mg/kg. New vessel formation and the expression of ephrinB2/VEGFR2 signaling pathway components were examined 14days after MCAO to examine angiogenesis and the associated mechanisms. The dynamics of regional cerebral blood flow (rCBF) and the number of vessels of the leptomeningeal anastomoses were analyzed to characterize microvascular circulation 3days after MCAO. We demonstrated that morroniside promoted angiogenesis by regulating the ephrinB2/VEGFR2 signaling pathway 14days post-ischemia. By 3days post-ischemia, morroniside improved rCBF and increased the number of vessels of the leptomeningeal anastomoses. Moreover, morroniside decr...

Source: Brain Research Bulletin - September 6, 2016 Category: Neurology Authors: Liu T, Xiang B, Guo D, Sun F, Wei R, Zhang G, Ai H, Tian X, Zhu Z, Zheng W, Wang Y, Wang W Tags: Brain Res Bull Source Type: research