Hypoxia-Inducible Factor-1 α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.

CONCLUSIONS: These findings suggest that HIF-1α induced by hypoxia activates the TGF-β/SMAD3 pathway. This mechanism may promote kidney injury, especially by upregulating genes related to fibrosis.
PMID: 27607351 [PubMed - as supplied by publisher]

Source: American Journal of Nephrology - September 8, 2016 Category: Urology & Nephrology Authors: Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H Tags: Am J Nephrol Source Type: research