Differentiation of parathyroid carcinoma and adenoma by preoperative ultrasonography.

Differentiation of parathyroid carcinoma and adenoma by preoperative ultrasonography. Acta Radiol. 2016 Sep 8; Authors: Nam M, Jeong HS, Shin JH Abstract BACKGROUND: Parathyroid carcinomas (PTC) are very rare. There have been a few studies on the contribution of ultrasound (US) in the diagnosis of PTC compared with parathyroid adenomas (PTA). PURPOSE: To identify the differences between US findings of PTC and PTA in patients with primary hyperparathyroidism (PHPT). MATERIAL AND METHODS: We enrolled seven patients with PTC and 32 consecutive patients with PTA whose diagnoses were confirmed by surgery at our institution between March 1994 and June 2015. We retrospectively compared the US features of the two groups, as well as the demographic, clinical, and biochemical characteristics (age, gender, palpability, and serum ionized calcium and parathyroid hormone [PTH] levels). RESULTS: The patients with PTC and PTA did not exhibit significant differences in terms of mean age (59.0 years versus 51.1 years; P = 0.2063), sex distribution (male:female, 4:3 versus 1:3; P = 0.1716), mean PTH levels (2855.0 pg/mL versus 1821.5 pg/mL; P = 0.2067), and mean ionized calcium levels (1.7 mMol/L versus 1.5 mMol/L; P = 0.1585) except palpability (P 
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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To identify the differences between ultrasound (US) features of parathyroid carcinoma (PC) and benign parathyroid (BP) lesions in patients with primary hyperparathyroidism (PHPT).
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
ConclusionIn patients with CRF it’s difficult to diagnose parathyroid carcinoma, because its presentation mimics the most common secondary hyperparathyroidism; the concomitant presence of metastases should lead us to suspect malignant parathyroid lesions.Surgery is the only effective therapy and therefore should be always performed.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsUltrasonic features in combination with iPTH level may be an applicable model for predicting PC and has a better potential to facilitate decision-making preoperatively.
Source: Endocrine - Category: Endocrinology Source Type: research
CONCLUSION: Even if literature does not support a syndromic association between neurofibromatosis type 1 and primary hyperparathyroidism, the benefit of precociously diagnosing and treating this condition may outweigh costs associated with screening. This case report moreover demonstrates that sometimes clinical, laboratory and imaging aspects suspicious for cancer may be missing. A prompt referral to a high-volume center is crucial for the management of those cases of incidental histopathological diagnosis. PMID: 30198445 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
AbstractIn Western countries, the presentation of primary hyperparathyroidism (PHPT) changed from a symptomatic to an asymptomatic disease after the 1970s, whereas in China, only one study has evaluated the changing clinical characteristics and biochemical profiles of PHPT patients. The aim of this study was to explore changes in the clinical characteristics of PHPT in Chinese patients. Overall, 140 consecutive patients with PHPT were studied between January 1, 2010 and June 30, 2016. The patients were divided into two groups: 32 consecutive patients from January 1, 2010 to March 31, 2013 were included in group 1, and 108 ...
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research
Rationale: Parathyroid carcinoma is a rare endocrine malignancy. Acute pancreatitis as an initial manifestation of parathyroid carcinoma has been rarely reported. Patient concerns: A 22-year-old woman was admitted to emergency room with a sudden attack of severe epigastric pain. Diagnoses: Acute pancreatitis was diagnosed as elevated levels of serum amylase. During the work-up for acute pancreatitis, patient's abnormally increased serum calcium and bones destruction revealed by abdominal computed tomography (CT) scan raised the suspicion of hyperparathyroidism or malignancy. Elevated serum parathyroid hormone (PTH)...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In conclusion, synchronous thyroid surgery was carried out in a quarter of all parathyroidectomy procedures performed for treatment of primary hyperparathyroidism. Coincidental thyroid pathology was c ommon. The limitations of pre-operative imaging in reliably locating involved parathyroid tissue are demonstrated and the importance of considering the potential need to perform thyroid surgery during parathyroidectomy and obtaining appropriate informed consent.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Authors: Cao C, Dou C, Chen F, Wang Y, Zhang X, Lai H Abstract Parathyroid carcinoma (PTCA) is a rare disease, and ectopic PTCA is particularly rare. Parathyroid hormone-related protein (PTHrP) expression in PTCA has not been previously described in the relevant literature to the best of our knowledge. The present study reports a unique case with a mediastinal parathyroid carcinoma producing parathyroid hormone (PTH) and PTHrP. A 53-year-old man presented with hyperparathyroidism symptoms, including fatigue, chest pain, dizziness, muscular soreness, polyuria, night sweats and renal stones. However, neck ultrasound ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
We describe the coexistence of rare late manifestations of HPT, which had not been adequately investigated at their onset in this young patient. Therefore, increased awareness is needed in order to recognize and further investigate signs or symptoms of HPT. PMID: 27252748 [PubMed]
Source: Clinical Cases in Mineral and Bone Metabolism - Category: Orthopaedics Tags: Clin Cases Miner Bone Metab Source Type: research
We report a 50-year-old male patient who was referred to our Department for a right thyroid nodule, incidentally detected on carotid Doppler ultrasound scan, with a fine-needle aspiration cytology showing a follicular lesion. At the time of our evaluation, neck ultrasound showed a 1.3 cm right hypoechoic thyroid nodule with irregular margins and the absence of enlarged bilateral cervical lymph nodes. Thyroid function tests were normal. Serum calcium was normal and plasma PTH slightly above the upper limit of the normal range. The patients underwent right lobectomy. The intraoperative frozen-section pathological examin...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Source Type: research
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