Culex mosquitoes are experimentally unable to transmit Zika virus.

We report that two laboratory colonies of Culex quinquefasciatus and Culex pipiens mosquitoes were experimentally unable to transmit ZIKV either up to 21 days post an infectious blood meal or up to 14 days post intrathoracic inoculation. Infectious viral particles were detected in bodies, heads or saliva by a plaque forming unit assay on Vero cells. We therefore consider it unlikely that Culex mosquitoes are involved in the rapid spread of ZIKV. PMID: 27605159 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research

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L. Rossi Evolutionary theory indicates that virus virulence is shaped by a trade-off between instantaneous rate of transmission and duration of infection. For most viruses, infection is curtailed by immune clearance, but there are few empirical tests of the transmission–clearance trade-off hypothesis. We exposed A129 mice to bites from groups of 1, 2–4, or 6–9 Aedes albopictus mosquitoes infected with Zika virus (ZIKV). We predicted that a higher number of infectious mosquito bites would deliver a higher total dose of the virus, and that increasing dose would result in earlier onset, high...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
(University of Saskatchewan) Using a relevant animal model (pigs), University of Saskatchewan researchers have shown that mild Zika virus infection in fetuses can cause abnormal brain development in apparently healthy young animals. The study, published Nov. 14, 2019 in PLOS Pathogens, provides new insights into the potential outcomes of Zika virus infection and could point to new prevention and treatment strategies to alleviate the long-term effects of Zika virus infection.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Lu Lu Recently, Zika virus (ZIKV) has attracted much attention in consideration of its association with severe neurological complications including fetal microcephaly. However, there are currently no prophylactic vaccines or therapeutic drugs approved for clinical treatments of ZIKV infection. To determine the potential anti-ZIKV inhibitors, we screened a library of clinical drugs with good safety profiles. Erythromycin estolate (Ery-Est), one of the macrolide antibiotics, was found to effectively inhibit ZIKV infection in different cell types and significantly protect A129 mice from ZIKV-associated neurological sign...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The objective of this study was to evaluate the anti-ZIKV IgG prevalence in blood donors from the Northeast region of the S ão Paulo State, Brazil, which experienced a ZIKV outbreak in 2016.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: RESEARCH ARTICLE Source Type: research
ABSTRACTAedes aegyptiandAedes albopictusare invasive mosquito species with geographic ranges that have oscillated within Florida since their presence was first documented. Local transmission of dengue, chikungunya, and Zika viruses serves as evidence of the public health importance of these two species. It is important to have detailed knowledge of their distribution to aid in mosquito control efforts and understand the risk of arbovirus transmission to humans. Through a partnership involving the University of Florida Institute of Food and Agricultural Sciences Cooperative Extension Service and the Florida Medical Entomolo...
Source: Journal of Vector Ecology - Category: Biology Authors: Tags: Original Article Source Type: research
Authors: Maniero VC, Rangel PSC, Coelho LMC, Silva CSB, Aguiar RS, Lamas CC, Cardozo SV Abstract A progressive increase in the circulation of arboviruses in tropical countries has been observed, accounting for 700,000 yearly deaths in the world. The main objective of this article was to identify the presence of Zika (ZIKV), dengue (DENV), and Chikungunya (CHIKV) viruses in immature stages of Aedes aegypti and Ae. albopictus. Household collections of immature phases of the vectors were carried out in the years 2015 and 2016. A total of 2902 dwellings were visited and the rate of infestation with larvae and pupae of ...
Source: Brazilian Journal of Medical and Biological Research - Category: Research Tags: Braz J Med Biol Res Source Type: research
(Baylor College of Medicine) Researchers have discovered that the Zika virus protein NS4A disrupts brain growth by hijacking a pathway that regulates the generation of new neurons.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
(Integral Molecular) The NIH has awarded Integral Molecular a contract which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and equine encephalitis viruses (EEV), aiding the discovery of vaccines and therapeutics against these currently untreatable and often lethal viruses.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
A. Shoukat et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
(PLOS) Zika virus infection in the womb produces altered immune responses and sex-specific brain abnormalities in apparently healthy pig offspring, according to a study published Nov. 14 in the open-access journal PLOS Pathogens by Uladzimir Karniychuk of the University of Saskatchewan, and colleagues.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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