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Bone mineral density is reduced by telmisartan in male spontaneously hypertensive rats.

CONCLUSION: Results showed that telmisartan negatively affected bones suggesting that caution should be taken in possible therapeutic applications for protecting bone health in hypertensive conditions. More studies are necessary to clarify the mechanisms through which telmisartan favors bone loss in this model. PMID: 27607362 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rep Source Type: research

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The objective of the current study was to test the feasibility of our strategy. Newborn rat calvarial osteoblasts were treated by 50  Hz 1.8 mT sinusoidal electromagnetic fields (SEMFs) with 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 h/days, respectively. The osteogenic differentiation and maturation of the osteoblast were assayed and compared to obtain the optimal duration. One-month-old growing rats were then treated by the same SEMFs with 0.5, 1.5, and 2.5 h/days, respectively, and the peak bone mass was analyzed after 2 months. It was found that the optimal exposure duration to promote the osteogenic dif...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Conclusion Neck circumference is an alternative measure to estimate body fat and as an additional marker to screen for cardiovascular risk diseases.RESUMO Objetivo Investigar a associa ção da circunferência do pescoço com fatores de risco cardiometabólico e escore de risco de Framinghan. Métodos Estudo transversal de base populacional com 948 adultos (522 mulheres), de 20 a 59 anos. Fatores sociodemográficos, antropométricos, de composição corporal, comportamentais, bio químicos e hemodinâmicos foram mensurados. Associação entre...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
Authors: Kang KY, Chung MK, Kim HN, Hong YS, Ju JH, Park SH Abstract OBJECTIVE: To examine factors related to a low trabecular bone score (TBS) and the association between TBS and vertebral fractures in patients with ankylosing spondylitis (AS). METHODS: One hundred patients (all male, aged
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
AbstractObjective:To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause.Methods:Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m2/min), and femoral muscle ...
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
In conclusion, although BMC values were found to be more accurate in women, HFBIA overestimated BMC compared to DXA, especially in individuals with lower values. Given these results, using HFBIA to measure BMC would be inappropriate for diagnostic purposes. PMID: 29345171 [PubMed - as supplied by publisher]
Source: International Journal of Sport Nutrition and Exercise Metabolism - Category: Sports Medicine Authors: Tags: Int J Sport Nutr Exerc Metab Source Type: research
Abstract We have previously documented improvements in endothelium‐dependent vasodilation with a Bikram (hot) yoga intervention in middle‐aged adults. Presently, the effect of environmental temperature in hot yoga on endothelial function is unknown. PurposeThe purpose of this investigation was to determine the effects of Bikram yoga interventions performed in the heated and thermoneutral conditions on endothelium‐dependent vasodilation. MethodsFifty‐two sedentary but apparently healthy adults aged 40–60 years were randomly assigned to one of three groups: Bikram yoga practiced at 40.5°C (n =&nbs...
Source: Experimental Physiology - Category: Physiology Authors: Tags: RESEARCH PAPER Source Type: research
ConclusionsLow- and heavy-load resistance exercise elicited similar acute responses in arm swelling and breast cancer–related lymphedema symptoms in women at risk for lymphedema receiving adjuvant taxane-based chemotherapy. These represent important preliminary findings, which can be used to inform future prospective evaluation of the long-term effects of repeated exposure to heavy-load resistance exercise. Purpose Despite a paucity of evidence, prevention guidelines typically advise avoidance of heavy lifting in an effort to protect against breast cancer–related lymphedema. This study compared acute respon...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Clinical Sciences Source Type: research
Purpose of review To summarize the recent developments in endocrine disorders associated with Down syndrome. Recent findings Current research regarding bone health and Down syndrome continues to show an increased prevalence of low bone mass and highlights the importance of considering short stature when interpreting dual energy x-ray absorptiometry. The underlying cause of low bone density is an area of active research and will shape treatment and preventive measures. Risk of thyroid disease is present throughout the life course in individuals with Down syndrome. New approaches and understanding of the pathophysiology...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: GROWTH AND DEVELOPMENT: Edited by Lynne L. Levitsky Source Type: research
Authors: Tsuchida K, Fujihara Y, Hiroki J, Hakamata T, Sakai R, Nishida K, Sudo K, Tanaka K, Hosaka Y, Takahashi K, Oda H Abstract In patients with chronic heart failure (HF), the clinical importance of sarcopenia has been recognized in relation to disease severity, reduced exercise capacity, and adverse clinical outcome. Nevertheless, its impact on acute decompensated heart failure (ADHF) is still poorly understood. Dual-energy X-ray absorptiometry (DXA) is a technique for quantitatively analyzing muscle mass and the degree of sarcopenia. Fat-free mass index (FFMI) is a noninvasive and easily applicable marker of ...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
ConclusionsLow- and heavy-load resistance exercise elicited similar acute responses in arm swelling and breast cancer–related lymphedema symptoms in women at risk for lymphedema receiving adjuvant taxane-based chemotherapy. These represent important preliminary findings, which can be used to inform future prospective evaluation of the long-term effects of repeated exposure to heavy-load resistance exercise. Purpose Despite a paucity of evidence, prevention guidelines typically advise avoidance of heavy lifting in an effort to protect against breast cancer–related lymphedema. This study compared acute respon...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Clinical Sciences Source Type: research
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