Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in < i > Leishmania major < /i >

Conclusions/SignificanceThis study demonstrated for the first time that TRP is associated with TUB resistance inLeishmania. The next challenge is to determine how TRP mediates TUB resistance and whether purine metabolism is affected by this protein in the parasite. Finally, these findings may be helpful for the development of alternative anti-leishmanial drugs that target purine pathway.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research