Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells

Conclusion
These results suggest that nucleosomes and its signalling in B and T cells contribute to disease development in SSc via TLR9.

Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: Yoshizaki, A., Taniguchi, T., Saigusa, R., Fukasawa, T., Ebata, S., Numajiri, H., Nakamura, K., Yamashita, T., Takahashi, T., Toyama, T., Asano, Y., Tedder, T. F., Sato, S. Tags: Immunology (including allergy), Interstitial lung disease, Connective tissue disease Basic and translational research Source Type: research