GI highlights from the literature

Basic scienceCARD9, the microbiota and tryptophan in intestinal homeostasis Lamas B, Richard ML, Leducq V, et al. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med 2016;22:598–605. doi:10.1038/nm.4102 Genetics, environment and diet influence the composition of the gut microbiota. A change in any of these factors results in a dysbiosis, and this contributes to the pathogenesis of IBD. CARD9 is a susceptibility gene for IBD that is involved in immune responses against microorganisms. Card9 knockout mice (Card9–/–) are more susceptible to colitis and have an increased load of gut-resident fungi, and CARD9 promotes recovery from colitis through interleukin (IL)-22 pathway activation. Recent data have suggested that tryptophan catabolites generated by microbiota metabolism play a role in mucosal immune responses. In the present study, Lamas and colleagues investigated the interaction between CARD9, the microbiota and tryptophan in intestinal homeostasis....
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research