New Wnt/{beta}-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals

Conclusions We identified new direct Wnt/β-catenin target genes, BOP1, CKS2 and NFIL3, which induced EMT, cell migration and experimental metastasis of CRC cells. These genes crosstalk with different downstream signalling systems, and activate migration-promoting genes. These pathways and downstream genes may serve as therapeutic targets in the treatment of CRC metastasis.

http://gut.bmj.com/cgi/content/short/65/10/1690?rss=1

Source: Gut - September 7, 2016 Category: Gastroenterology Authors: Qi, J., Yu, Y., Akilli Öztürk, O., Holland, J. D., Besser, D., Fritzmann, J., Wulf-Goldenberg, A., Eckert, K., Fichtner, I., Birchmeier, W. Tags: Colon cancer Source Type: research