Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD

Conclusions
This study provides the first evidence of CXCR1+CXCR2+IL-23-producing neutrophils that infiltrate and accumulate in inflamed colon tissue of patients with IBD. Thus, this novel source of IL-23 may play a key role in disease progression and will be important to take into consideration in the development of future strategies to monitor, treat and prevent IBD.

Source: Gut - September 7, 2016 Category: Gastroenterology Authors: Kvedaraite, E., Lourda, M., Ideström, M., Chen, P., Olsson-Akefeldt, S., Forkel, M., Gavhed, D., Lindforss, U., Mjösberg, J., Henter, J.-I., Svensson, M. Tags: Inflammatory bowel disease Source Type: research