Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor- α Levels in Chronic Kidney Disease - A 5-Year Prospective Study.
CONCLUSION: Monocytes in CKD stages 2-3 show emerging functional abrasions, with altered adhesion molecule expression and impaired fMLP response. These findings suggest that a transformation of monocyte function occurs at an early phase of renal impairment and may together with increased plasma levels of pro-inflammatory cytokines contribute to the higher vulnerability of CKD patients to comorbidities, such as infections and cardiovascular disease.
PMID: 27603798 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Wallquist C, Mansouri L, Norrbäck M, Hylander B, Jacobson SH, Lundahl J Tags: Am J Nephrol Source Type: research
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