From Chronic Kidney Disease To The Gift Of A New Life

Authors: Julika Wocial (JW) and Michael Moore (MM) MM The need for a donor After being diagnosed with chronic kidney disease I was able to lead a full and productive life for 25 years, although more recently my energy sagged. Looming options were dialysis, the 5-7 year wait for a deceased donor or a living donor. Dr Google said A living donor was the best option. But how? It must be different for each patient - a direct ask seemed weird, but silence was not an option. Happily I had made no secret of my lousy kidneys thus, 'How you doing?' lead on to the need. JW What it means to consider living donation I met Michael 18 years ago: my mentor and colleague. One day he told me his kidneys were failing; he needed a kidney transplant. After initial shock of the news and trying to figure out what it meant for him I started spending every free minute researching kidney diseases. A kidney transplant from a living donor was the best option - allowing Michael to live many more years. I asked myself - is there anything stopping me from being his donor? The surgery risks were minimal and I was willing to take them, the short and long-term consequences - four weeks out of work, four small scars, and lifting limitations for 3 months... All the literature out there, article after article, was proving that living donors live long and perfectly normal lives even 30 years after donation. The answer was simply NO... And shortly after, I told Michael I would like to be cons...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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CONCLUSION: The consistent application of the existing multimodal treatment options for glioma has led in recent years to improved survival. Areas of important current and future scientific activity include immunotherapy and targeted and combined chemotherapy, as well as altered neurocognition, modern approaches to palliative care, and complementary therapies. PMID: 29914619 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Roque M, Bianco B, Christofolini DM, Cordts EB, Vilarino FL, Carvalho W, Valle M, Sampaio M, Geber S, Esteves SC, Barbosa CP Abstract Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. There is a group of patients that present with a suboptimal response to...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer, Published online: 21 June 2018; doi:10.1038/s41397-018-0030-8Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, di fferentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment. Two PTPs that have an important inhibitory role in haemato...
Source: Oncology - Category: Cancer & Oncology Source Type: research
The study is potentially a “leap forward” in cancer genomics, particularly for subsets of patients with metastatic and anaplastic thyroid cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
In the Utah Cancer Survivors Study, male thyroid cancer survivors had an almost 50% higher risk of developing cardiovascular disease than females.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
AbstractDespite significant advances in our ability to treat cancer, cytotoxic chemotherapy continues to be the mainstay treatment for many solid tumours. Chemotherapy is commonly associated with a raft of largely manageable adverse events; however, gastrointestinal (GI) toxicity (also termed mucositis) remains a significant challenge with little in the way of preventative and therapeutic options. The inability to manage GI complications likely reflects our incomplete understanding of its aetiology and the idiosyncrasies of each chemotherapeutic agent. This review highlights aims to provide a narrative for the involvement ...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Saby George, MD, FACP, Roswell Park Cancer Institute, shares CARMENA Study Results | Sunitinib Not Inferior to Sunitinib Following Nephrectomy at ASCO 2018 Author: Annual-Meeting Added: 06/20/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Saby George, MD, FACP, Roswell Park Cancer Institute, explains Checkmate-214 has a Higher Response Rate | 9% of Patients Went on to Complete Response at ASCO 2018 Author: Annual-Meeting Added: 06/20/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Authors: Makrigiannakis A, Vrekoussis T, Zoumakis E, Hatzidakis V, Vlachou E, Salakos N, Kalantaridou SN Abstract Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
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