From Chronic Kidney Disease To The Gift Of A New Life

Authors: Julika Wocial (JW) and Michael Moore (MM) MM The need for a donor After being diagnosed with chronic kidney disease I was able to lead a full and productive life for 25 years, although more recently my energy sagged. Looming options were dialysis, the 5-7 year wait for a deceased donor or a living donor. Dr Google said ihatedialysis.com. A living donor was the best option. But how? It must be different for each patient - a direct ask seemed weird, but silence was not an option. Happily I had made no secret of my lousy kidneys thus, 'How you doing?' lead on to the need. JW What it means to consider living donation I met Michael 18 years ago: my mentor and colleague. One day he told me his kidneys were failing; he needed a kidney transplant. After initial shock of the news and trying to figure out what it meant for him I started spending every free minute researching kidney diseases. A kidney transplant from a living donor was the best option - allowing Michael to live many more years. I asked myself - is there anything stopping me from being his donor? The surgery risks were minimal and I was willing to take them, the short and long-term consequences - four weeks out of work, four small scars, and lifting limitations for 3 months... All the literature out there, article after article, was proving that living donors live long and perfectly normal lives even 30 years after donation. The answer was simply NO... And shortly after, I told Michael I would like to be cons...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Nae Yu Kim, Jung-Soo Pyo, Dong-Wook Kang, Seung-Min YooAbstractObjectiveThe aim of this study was to elucidate the clinicopathological significance and prognostic role of loss of claudin-1 in colorectal cancer (CRC).MethodsThe correlations between claudin-1 expression and clinicopathological characteristics, including survival rates, were assessed using immunohistochemistry on 260 archival, paraffin-embedded CRC tissues. In addition, the correlations between cludin-1 and nuclear factor-kappa B (NF-κB), epithelial-mes...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study investigated the possibility of using umbilical cord mesenchymal stem cells (MSCs) as cellular carriers of IFN-β.Isolated umbilical cord MSCs were transfected with a lentivirus packaging IFN-β-overexpression plasmid. A549 cells were subcutaneously injected into nude mice to establish a non-small cell lung cancer (NSCLC) mouse model. A total of 50 mice were randomly assigned to 5 different groups: a control group, IFN-β group, IFN-β-MSCs group, MSCs-lentivirus group, and MSCs group. Next, the IFN-β-MSCs, MSCs-lentivirus, and MSCs were injected into the A549 lung cancer-bearing mice in the...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Cong-Cong Wu, Zhi-Jun SunAbstractExpression of the family with sequence similarity 3 member C (FAM3C) is necessary for the epithelial-mesenchymal transition (EMT). However, the expression level and clinicopathological significance of FAM3C in oral squamous cell carcinoma (OSCC) has not been thoroughly elucidated to date. We performed immunohistochemical staining on human OSCC specimens with FAM3C, co-inhibitory immune checkpoints, EMT markers, and cancer stem cells (CSCs) markers to analyze the expression levels and clinic...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Xin Gong, Xiaoyun Liao, Mengyi HuangAbstractIncreasing evidence reveal the important role of long non-coding RNAs (lncRNAs) in the initiation and progression of glioma. However, the role of lncRNA cancer susceptibility candidate 7 (CASC7) in glioma is largely unknown. At first, the expression level of CASC7 was tested in glioma tissues and cell lines by using qRT-PCR. We applied Kaplan-Meier method to analyze the correlation between the expression level between CASC7 expression and the overall survival rate of glioma patie...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 14 January 2019Source: Pathology - Research and PracticeAuthor(s): Aili Tan, Ruoyu Luo, Peng RuanAbstractEndometrial cancer (EC) is a huge threat to women’s health. The aims of this study were to investigate the role of microRNA (miR)-495 in the proliferation and apoptosis of EC cells in vitro. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to detect the mRNA levels. In addition, dual-luciferase reporter assay was used to verified that PIK3R1 was a target of miR-495. After transfection with miR-495 mimics, Cell Counting Kit 8 (CCK-8) assay was p...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
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Source: Acta Paulista de Enfermagem - Category: Nursing Source Type: research
Resumo Objetivo: Avaliar a influ ência do tempo de exposição e calibre na formação de biofilme em cateteres urinários de Foley (CUFs). Método: Pesquisa in vitro com amostras de fragmentos de CUFs em látex siliconizado de diferentes calibres (n° 14 e n° 16 Frenchs). A urina artificial foi confeccionada, inoculada com bact érias-padrão Staphylococcus aureus (ATCC 25923) e Pseudomonas aeruginosa (ATCC 27853) e incubada a 37 °C por 24 horas e 72 horas. As análises foram realizadas por meio de cultura (carga bacteriana) e microscopia eletr&o...
Source: Acta Paulista de Enfermagem - Category: Nursing Source Type: research
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