Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina

AbstractTwo new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (3–5) were isolated from the roots ofDalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC50 values in the range 3.47 –9.76 µM. In addition, compound3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC50 values of 8.29 and 9.54  µM, respectively, and compound2 showed significant cytotoxicity against the MCF-7 cell line, with an IC50 value of 4.69  µM.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
In this study, we demonstrate the use of lipids as co-surfactants for the preparation of mixed micelles to improve the siRNA delivery of cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were polymerized on the surface of cholic acid to afford a star-shaped block copolymer with four arms (CA-PAGE-b-PEG)4. The allyl groups of PAGE were functionalized to bear primary or tertiary amines and folic acid was grafted onto the PEG chain end to increase cell uptake. (CA-PAGE-b-PEG)4 functionalized with either primary or tertiary amines show high siRNA complexation with close to 10...
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