Mango and the microbiota: Potential role of this superfruit in maintaining gut health

(Wild Hive) Research published in the Journal of Nutrition has for the first time, documented the potential effects of mango consumption on gut microbiota of mice. When samples were compared from the beginning to the end of the study period, mango supplementation was found to prevent the loss of beneficial gut bacteria often induced by a high-fat diet. This is an important finding as specific bacteria in the intestinal tract may play a role in obesity and obesity-related complications, such as type 2 diabetes.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Haddad JA, Haddad AN Abstract There is today an exponential increase in prevalence of type 2 diabetes mellitus (T2DM), especially in young people. This downward shift in age of onset of T2DM has been shown by abundant evidence to be due to an increase in obesity among the young, the latter mainly attributable to unhealthy dietary habits and a sedentary lifestyle. It is therefore obvious that the prevention of diabetes rather its treatment is of is paramount importance. In the past decade, because concerns about the safety of antidiabetic agents took precedence over the issue of efficacy, almost all studies...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
AbstractBackgroundLaparoscopic sleeve gastrectomy (LSG) has become an increasingly popular metabolic surgical procedure. Alteration in motor gastric function is a fundamental feature following LSG but still remains controversial.PurposeTo determine the gastric emptying time 3  month after LSG, correlations between gastric emptying time and body weight, weight loss, and glycemia levels, alongside determining predictive factors of weight loss at the 3-month follow-up.Materials and MethodsTwenty-one patients were recruited in this study. Gastric emptying time was measured using a standard solid-phase gastric emptying sca...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionLSG has a significant effect on patients with type 2 diabetes mellitus whose BMI less than 30  kg/m2 in a short time, but its long-term effectiveness needs to be further followed up.
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractWhite adipose tissue is a highly plastic organ and is an important regulator of whole-body metabolism and energy balance. The magnitude of adipose tissue mass is determined by dynamic changes in the synthesis and breakdown (i.e. turnover) of adipocytes and triacylglycerols (TGs). Obesity is a disorder characterised by excessive adiposity and is a risk factor for diseases, including the metabolic syndrome and type 2 diabetes. Adipose tissue expansion is necessary to accommodate chronic excess energy intake and is characterised by enlargement of existing adipocytes (hypertrophy) and by increase in pre-adipocyte and a...
Source: Diabetologia - Category: Endocrinology Source Type: research
AbstractAims/hypothesisIndividuals of South Asian origin are at increased risk of developing type 2 diabetes mellitus and associated comorbidities compared with Europids. Disturbances in energy metabolism may contribute to this increased risk. Skeletal muscle and possibly also brown adipose tissue (BAT) are involved in human energy metabolism and nitric oxide (NO) is suggested to play a pivotal role in regulating mitochondrial biogenesis in both tissues. We aimed to investigate the effects of 6  weeks of supplementation withl-arginine, a precursor of NO, on energy metabolism by BAT and skeletal muscle, as well as gluc...
Source: Diabetologia - Category: Endocrinology Source Type: research
Authors: Dhindsa S, Chemitiganti R, Ghanim H, Santiago E, Haider A, Chaar N, Mok M, McKee A, Dandona P Abstract A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 ...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
We thank the authors for their interest and comments on our article “Metabolic Surgery Ameliorates Cardiovascular Risk in Obese Diabetic Patients: Influence of Different Surgical Procedures” [1]. Owing to the increasing of obesity epidemic, type 2 diabetes mellitus (T2D) is becoming a major health issue, in both developed and developing countries. It is estimate d that more than 425 million individuals were affected by T2DM worldwide in 2017 with a global prevalence of 1(9.9%) in 11 adults [2]. Therefore, T2D becomes an important health issue than obesity in some areas of the world.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Letter to Editor Source Type: research
Melatonin in type 2 diabetes mellitus and obesity, Published online: 07 December 2018; doi:10.1038/s41574-018-0130-1Type 2 diabetes mellitus and obesity are major public health challenges; emerging evidence suggests that melatonin is involved in the development of these disorders, opening new avenues for research. This Review discusses the effect of melatonin and its receptors on glucose homeostasis, obesity and type 2 diabetes mellitus.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research
In this study, the effects of BCLE on obese diabetes were investigated using the KK-Ay mice. The component F2 of BCLE alleviate hyperglycemia and insulin resistance, as indicated by decreased levels of FBG, AUC, GSP, LDH and insulin. High levels of hepatic G6Pase and PEPCK in KK-Ay mice were markedly attenuated by F2. The inhibitory effect of F2 on GSK-3β and the enhancement effect on liver glycogen demonstrated that F2 could significantly inhibit hepatic gluconeogenesis and glycogen accumulation. The higher PPAR γ showed F2 may prevent insulin resistance by PI3K signal transduction pathway. In addition, the com...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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