Three new ent -kaurane diterpenes from the herbs of Wedelia prostrata

AbstractThree newent-kaurane diterpenes, 3α-angeloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (1), 3α-tigloyloxy-17-hydroxy-ent-kaur-15-en-19-oic acid (2) and 3α-cinnamoyloxykaur-9(11),16-dien-19-oic acid (3), along with five known compounds (4-8), were isolated from the herbs ofWedelia prostrata (Asteraceae). The structures were determined by extensive analysis of their spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolated compounds were evaluated for their cytotoxic activity on human hepatocellular carcinoma HepG2 cells. Among them, all isolates exhibited cytotoxic activities with IC50 values ranging from 9.55  ± 0.45 to 53.92 ± 1.22 μM.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

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Publication date: June 2020Source: Biomedicine &Pharmacotherapy, Volume 126Author(s): Dafeng Xu, Xiangmei Liu, Yu Wang, Kailun Zhou, Jincai Wu, Jia cheng Chen, Cheng Chen, Liang Chen, Jinfang Zheng
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
About 30% of HCC patients showed negative serum AFP and had special clinicopathologic characteristics and prognosis. We developed and validated nomograms for predicting prognosis of patients with AFP ‐negative HCC after radical resection. Our novel nomograms presented superior performance and discrimination ability than conventional staging systems based on the C‐indexes, calibration curves, decision curve analysis and Kaplan‐Meier curves, which were proposed for clinical decision. AbstractBackgroundTo develop and validate nomograms that can be used to predict outcomes in individuals suffering alpha ‐fetoprotein (A...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We report here on doxorubicin (DOX)‐loaded polyphosphate glass microspheres (PGM) as a no vel resorbable, radiopaque, preloaded DEB‐TACE platform. Coacervate composed of polyphosphate chains complexed with Ba2+, Ca2+, and Cu2+ can be loaded with DOX prior to PGM synthesis, with PGM production achieved using a water ‐in‐oil emulsion technique at room temperature yielding highly spherical particles in clinically relevant size fractions. In vitro, DOX release was found to be linear, pH dependent, and in accordance with Type II non‐Fickian transport. PGM degradation was characterized by an initial burst rele ase of d...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: ORIGINAL RESEARCH REPORT Source Type: research
Authors: Chu KK, Wong KH, Chok KS Abstract During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding ever since. The aim of this review is to provide an overview of such an expansion of scope. Various criteria have been proposed to expand the eligibility of patients with hepatocellular carcinoma exceeding the Milan criteria for liver transplant. Furthermore, l...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
The expression of the extracellular sulfatase SULF2 has been associated with increased hepatocellular carcinoma (HCC) growth and poor patient survival. However, the molecular mechanisms underlying SULF2-associated tumor growth remain unclear. To address this gap, here we developed a transgenic mouse overexpressing Sulf2 in hepatocytes under the control of the transthyretin promoter. In this model, Sulf2 overexpression potentiated diethylnitrosamine-induced HCC. Further analysis indicated that the transcription factor GLI family zinc finger 1 (GLI1) mediates Sulf2 expression during HCC development. A cross of the Sulf2-over...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
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Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
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Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
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