New Study on Physician-Industry Relationships, This Time Focused on Ophthalmologists

This study, published by JAMA Ophthalmology, compared the use of anti-vascular endothelial growth factor (VEGF) intravitreal injections by United States ophthalmologists to industry payments those same physicians received. Once again, the authors behind the study acknowledged that “Although the data can’t confirm a cause and effect, [they] found a positive association between reported pharmaceutical payments and increased use of drugs prescribed to treat problems of the retina.” This study reviewed data from the Centers for Medicare and Medicaid Services (CMS) 2013 Medicare Provider Utilization and Payment Data: Physician and Other Supplier Public Use File and the CMS-sponsored August through December 2013 Open Payments Program. Ophthalmologists who prescribe anti-VEGF injections for all indications were analyzed. The findings of the study were that a total of 3011 United States ophthalmologists were reimbursed by CMS for 2.2 million anti-VEGF injections in 2013 and, of those physicians, 38% reportedly received $1.3 million in industry payments for ranibizumab and aflibercept. According to the authors, further analysis “revealed positive associations between increasing numbers of reported industry payments and total injection use, aflibercept and ranibizumab injection use, and percentage of injections per physician that were aflibercept or ranibizumab.” Additionally, subgroup analysis further revealed that physicians who received between $1 a...
Source: Policy and Medicine - Category: American Health Authors: Source Type: blogs

Related Links:

Background/Purpose: The role of blood malondialdehyde (MDA) in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries, is still matter of debate. We performed a systematic review and meta-analysis of the published data on the MDA levels in AMD patients. Methods: PubMed, ISI Web of Sciences, and Scopus searches were performed according to MOOSE guidelines. Case–control studies were eligible for inclusion. Participants and controls were AMD patients and subjects without AMD, respectively. The main outcome measures were wet AMD and dry AMD. MDA level was the main expo...
Source: RETINA - Category: Opthalmology Tags: Review Source Type: research
Age-related macular degeneration (AMD) is a leading cause of blindness worldwide characterized by presence of drusen, leading to retinal pigment epithelium (RPE) and outer retinal changes in advanced stages. Approximately 10% of eyes with AMD develop neovascular complications and present with subretinal or sub-RPE exudation, hemorrhage, or both. Recent advances in imaging techniques, especially optical coherence tomography (OCT), help in early identification of disease and guide various treatment decisions; however, not all signs are suggestive of ongoing exudation or neovascular activity.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Major review Source Type: research
Authors: Cho C, Duong TT, Mills JA Abstract Patient-derived human-induced pluripotent stem cells (iPSCs) have been critical in advancing our understanding of the underlying mechanisms of numerous retinal disorders. Many of these retinal disorders have no effective treatment and result in severe visual impairment and even blindness. Among the retinal degenerative diseases modeled by iPSCs are age-related macular degeneration (AMD), glaucoma, Leber congenital amaurosis (LCA), retinitis pigmentosa (RP), and autosomal dominant retinitis pigmentosa (adRP). In addition to studying retinal disease ontogenesis and patholog...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
This study aims to evaluate the effect of loss of PNPLA2 in RPE cells undergoing oxidative stress. Loss of PNPLA2 conferred increased resistance to cells when subjected to oxidative stress. PMID: 31884641 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Skowronska-Krawczyk D, Chao DL Abstract Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide. Long-chain and very long-chain polyunsaturated fatty acids (LC and VLC-PUFAs) have been linked to AMD pathogenesis through epidemiologic, biochemical, and genetic studies; however, the exact mechanisms of pathogenesis are unknown. Here, we review the scientific and clinical evidence supporting the role of PUFAs in AMD and discuss future directions for elucidating the roles of these fatty acids in AMD pathogenesis. PMID: 31884586 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Schnabolk G Abstract Prevalence of age-related macular degeneration (AMD), the leading cause of blindness in the United States, increases greatly with age. While age is the greatest risk factor of AMD, other risks such as smoking, family history, complement pathway activation, and race exist. Various systemic inflammatory diseases share many of these risk factors with AMD, as well as a similar inflammatory profile. Due to these similarities, patient database studies analyzing the association between patients with various systemic diseases and AMD have been performed. In this review we will summarize recent...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Figueroa AG, McKay BS Abstract Age-related macular degeneration (AMD) is the most common cause of irreversible blindness. We do not know the cause of the disease and have inadequate prevention and treatment strategies for those at risk or affected. The greatest risk factors include age and race, with the white population at the highest risk for the disease. We developed the hypothesis that pigmentation in the retinal pigment epithelium (RPE) protects darkly pigmented individuals from AMD. We have tested this hypothesis in multiple ways including dissecting the pigmentation pathway in RPE using albinism-rel...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible blindness worldwide. Oxidative stress (OS), inflammation and genetics are considered the key pathogenic factors contribute to AMD development. Recent evidence shows the pro-inflammatory interleukin 17 (IL17) signaling is activated in AMD patients and promotes disease pathogenesis. However, the interplay between OS and IL17 signaling, and the regulatory mechanism of IL17 pathway are largely unknown. OS-induced retinal pigment epithelial cell (RPE) damage causes both the initial pathogenesis of AMD and secondary degeneration of rods a...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
Abstract Outer retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), are among the leading causes of incurable blindness in the Western world [1]. Retinal prostheses have been shown to restore some useful vision by electrically stimulating the remaining retinal neurons [2]. In contrast to inherited retinal degenerative diseases (e.g., RP), typically leading to a complete loss of the visual field, in AMD patients the disease is localized to the macula, leaving the peripheral vision intact. Implanting a retinal prosthesis in the central macula in AMD patients [3...
Source: Current Biology - Category: Biology Authors: Tags: Curr Biol Source Type: research
Abstract The retinal pigment epithelium [RPE] is a multifunctional monolayer located at the back of the eye required for the survival and function of the light-sensing photoreceptors. In Age-related Macular Degeneration [AMD], the loss of RPE cells leads to photoreceptor death and permanent blindness. RPE cell transplantation aims to halt or reverse vision loss by preventing the death of photoreceptor cells and is considered one of the most viable applications of stem cell therapy in the field of regenerative medicine. Proof-of-concept of RPE cell transplantation for treating retinal degenerative disease, such as ...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
More News: Age-Related Macular Degeneration (AMD) | Blindness | Cardiology | Endocrinology | Health | Health Medicine & Bioethics Commentators | Heart | Hematology | Learning | Lucentis | Medicaid | Medicare | Opthalmology | Ranibizumab Injection | Study | Universities & Medical Training | Washington University