Hypodontia prevalence and pattern in women with epithelial ovarian cancer.
Conclusions: The results statistically support possible association between EOC and hypodontia. Because hypdontia can be recognized early in life, this finding could possibly help in earlier detection of EOC, resulting in better prognosis and treatment in earlier stages of the disease. Earlier EOC diagnosis and treatment could save many lives. PMID: 24689849 [PubMed - as supplied by publisher]
Ovarian cancer is estimated to reach 22,530 diagnoses and cause 13,980 cancer deaths per year. The most common histology diagnosed of ovarian cancer is epithelial ovarian carcinomas (EOC). An aggressive epithelial subtype is clear cell ovarian carcinoma (CCOC) and is characterized as a non-serous ovarian cancer. Protein kinase C (PKC) is an enzymatic family of proteins that have been found to be a component in cancer progression, tissue invasion, and metastasis. The atypical PKC (aPKC) isoforms, PKC-ι and PKC-ζ, have been suggested to participate in the increased proliferation of ovarian cancers. Previous studies...
CONCLUSIONS: Taken together, the results of the present report suggest that WWOX can decrease Snail1 activity by enhancing the activity of Elf5, thus upregulating E-cadherin expression and eventually inhibiting EMT of ovarian carcinoma. PMID: 32096174 [PubMed - in process]
This study evaluated indications for PET/CT, impact of PET/CT results on EOC management, and its added value over conventional imaging.
Conditions: Ovarian Cancer; Hyperthermic Intraperitoneal Chemotherapy Intervention: Procedure: Hyperthermic Intraperitoneal Chemotherapy Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting
ConclusionsOur data indicate that EOCs may regulate the function of HPMCs through exosomal ITGA5B1/AEP, which may be crucial for peritoneal metastasis.
Authors: Dai Y, Jin S, Li X, Wang D Abstract [This corrects the article DOI: 10.18632/oncotarget.13817.]. PMID: 32064052 [PubMed - in process]
rrini Marina Fabbi We showed that IL-27 shares several effects with IFN-γ in human cancer cells. To identify novel extracellular mediators, potentially involved in epithelial ovarian cancer (EOC) biology, we analyzed the effect of IL-27 or IFN-γ on the secretome of cultured EOC cells by mass-spectrometry (nano-UHPLC-MS/MS). IL-27 and IFN-γ modulate the release of a limited fraction of proteins among those induced in the whole cell. We focused our attention on GBP1, a guanylate-binding protein and GTPase, which mediates several biological activities of IFNs. Cytokine treatment induced GBP...
Condition: Recurrent Epithelial Ovarian, Fallopian or Peritoneal Carcinoma Interventions: Drug: Carboplatin; Drug: Pegylated liposomal doxorubicin (PLD); Drug: Gemcitabine; Drug: Paclitaxel; Drug: Mirvetuximab Soravtansine Sponsor: AGO Research GmbH Not yet recruiting