How Effective is Oseltamivir?
Discussion Oseltamivir (Tamiflu®) is an oral neuraminidase inhibitor of influenza viruses types A and B. It first came on the market in Switzerland in 1999 and currently is used around the world along with other neuraminidase inhibitors to treat seasonal and pandemic influenza. Oseltamivir is easily absorbed from the gastrointestinal tract, and circulates to the liver where it is converted to its active metabolite oseltamivir carboxylate (OC). In adults approximately 75% of the oral medication is converted and it then travels to the upper and lower respiratory tracts. Unchanged oseltamivir is eliminated in the urine. OC “inhibits the conserved active site of the neuraminidase enzymes that are present as major surface antigens on all types of influenza viruses. As neuraminidase is essential for the release of progency virions from infected cells, inhibiting this enzyme limits the duration and severity of the infection.” OC half-life is about 1-2 hours and the maximal concentrations occur ~ 3-4 hours after administration. Children 50%. A 2014 Cochrane Review of the effectiveness of oseltamivir treatment included 107 clinical studies and 73 trials and found: For treatment of symptomatic patients, time to first symptom alleviation was reduced by 16.8 hours or from 7 to 6.3 days. In children the reduction was 29 hours. There was no change for asthmatic children. In children there was no significant effect on hospitalizations. There also were no significant reduc...
This study explored the association between serum vitamin D levels and urinary tract infections in pregnant women.Study designIn this case control study, 187 participants including, 97 pregnant women diagnosed as a symptomatic UTI (case group) and 90 matched healthy pregnant women (control group) were consecutively enrolled from prenatal care clinic of Imam Reza Hospital in Urmia, North West of Iran. The two groups were matched for trimester and parity, and sexual intercourse. Blood samples were collected from both groups. Chemiluminescent immunoassay (CLIA) was used to evaluate the serum vitamin D levels. We used a binary...
In conclusion, CWE seem to benefit from interventions and behavior modification techniques first developed for children with ADHD.
OBJECTIVE: To perform a descriptive analysis of preterm premature rupture of membranes (PPROM) cases attended in a tertiary hospital. METHOD: Retrospective analysis of medical records and laboratory tests of patients admitted to a Brazilian tertiary hospital between 2006 and 2011, with a confirmed diagnosis of PPROM and gestational age (GA) at delivery
ConclusionsThe most recent, newer technique employed appears to have an 80% success rate in improving sound tolerance with small changes to hearing. The improvement in hyperacusis symptoms after surgery is significant and now found to be sustainable with a mean follow-up of 2 years after initial surgery. Psychological measures of anxiety and depression also were found to be significantly improved after surgery in the newer technique group.
ConclusionsThe present study demonstrated that the Inula helenium and Grindelia squarrosa, which have been traditionally used in Europe as medicinal plants, are a valuable source of active compounds with anti-inflammatory activity. Our observations justify the traditional use of I. helenium and G. squarrosa for a treatment inflammation-based diseases in respiratory tract.Graphical abstract
Swedish DJ Tim Bergling, more widely known as Avicii, revolutionized electronic dance music. In April 2018, Bergling died by suicide while on vacation. He was 28. His father, Klas Bergling, spoke with "CBS This Morning" co-host Anthony Mason in his first U.S. broadcast interview.
ConclusionsWhile patient symptoms are important predictors of patient well-being, subjective appraisals of the stressfulness of symptoms, and of patients ’ self-efficacy in managing symptoms, are also key factors. The findings suggest the utility of a stress process model in understanding well-being in breast cancer patients, and point to the potential value of targeting patient appraisals as well as symptoms to improve psychological well-being and quality of life.
Publication date: December 2019Source: Molecular Immunology, Volume 116Author(s): Bijara Devi Sanasam, Sanjeev KumarAbstractMalaria caused by Plasmodium falciparum is the most deadly and a major health issue worldwide. In spite of several control programs, there hasn’t been much improvement in keeping the disease under control. The appearance of drug resistant strains of Plasmodium in addition to insecticide resistance of the Anopheles vector has been a hurdle. Therefore, it is highly desirable to identify new potential candidates that can be targeted for therapeutic intervention. The present study identifies AMR1, a...
UK drugmaker offloads assets as it focuses on profitable and new products
Conditions: Control of Pregnancy; Prevention of Sexually Transmitted Infections Interventions: Device: Polyurethane (PU) condom; Device: Natural Rubber Latex (NRL) condom Sponsor: Reckitt Benckiser Healthcare (UK) Limited Not yet recruiting
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