Vitamin D Intake Associated With Basal Cell Carcinoma Risk
Oral vitamin D intake was associated with an increased risk for basal cell carcinoma, but not melanoma, according to two large cohort studies.
Conclusions: Based on the literature and our experience, dermatologic surgery is safe without suspending antithrombotic therapy or antibiotic prophylaxis in patients with multiple comorbidity. PMID: 29681629 [PubMed - in process]
Abstract There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunosuppressive treatment was reported in 18 patients (3.2%). The standardized incidence ratio for developing SCC was 13.1 (95% confidence interval (95% CI) 6.5-19.7). Patients developing NMSC were older at the start ...
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the commonest skin malignancies and if diagnosed early have a good prognosis. Conversely, metastatic disease is rarely associated with a very poor prognosis. Locally advanced BCC is also uncommon and may not be amendable to surgery, radiation therapy or photodynamic therapy. The activation of the hedgehog pathway occurs in 90% of BCCs and inhibition of this pathway with well tolerated oral agents has resulted in an important therapeutic option in some patients with locally advanced or metastatic BCC. In contrast, metastatic SCC tends to behave biologically mo...
This article is protected by copyright. All rights reserved. PMID: 27510573 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved.
CONCLUSIONS: A Phase 3 study is now warranted to assess the chemopreventive efficacy of nicotinamide in renal transplant recipients. This article is protected by copyright. All rights reserved. PMID: 27061568 [PubMed - as supplied by publisher]
Conclusion These analyses confirm a previous finding of increased risk of BCC associated with MHT. Novel findings of increased BCC risk associated with MHT in women experiencing natural menopause and for late age at natural menopause warrant further investigation. Users of MHT may constitute an additional high-risk group in need of more frequent skin cancer screening.
New research suggests that oral nicotinamide (vitamin B3) reduces the incidence of new non-melanoma skin cancers (basal-cell carcinoma and squamous-cell carcinoma) and premalignant actinic keratoses in high-risk patients.
Conclusions The present study supports that relying on clinical diagnosis with the purpose to formalise a treatment plan for head and neck non-melanoma skin cancer is safe and efficient. This is more reliable in cases of basal cell carcinoma in comparison to suspected squamous cell carcinomas. Although positive predictive value represents a reliable measure of diagnostic accuracy, it is increased when populations with higher prevalence of the disease are studied.
Abstract Basal cell carcinomas (BCCs) account for around 80% of non-melanoma skin cancer. Australia has the highest incidence of BCC globally and the rates continue to increase in both Australia and New Zealand. BCC causes significant morbidity, placing an enormous burden on the healthcare system. Treatment of patients with advanced BCC can be particularly challenging. A panel of UK experts recently defined advanced disease as BCC that in which current treatment modalities are considered potentially contraindicated by clinical or patient-driven factors. Research has found that mutations in the hedgehog signalling ...