Prevalence of anti-SOX1 reactivity in various neurological disorders

Anti-SOX1 antibodies are associated with small cell lung cancer (SCLC) and predict a paraneoplastic etiology in Lambert-Eaton myasthenic syndrome (LEMS). In 2010, a study described these antibodies in a small cohort of putative non-paraneoplastic, immune-mediated neuropathies. In this respect, we investigated the seroprevalence and specificity of anti-SOX1 antibodies in a large cohort of neurological disorders.

Source: Journal of the Neurological Sciences - September 2, 2016 Category: Neurology Authors: Benjamin Berger, Rick Dersch, Elisabeth Ruthardt, Christiane Rasiah, Sebastian Rauer, Oliver Stich Source Type: research