Indoleamine 2,3-Dioxygenase (IDO) Activity During the Primary Immune Response to Influenza Infection Modifies the Memory T Cell Response to Influenza Challenge

Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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Authors: Thomas PG, Shubina M, Balachandran S Abstract Influenza A viruses (IAV) are members of the Orthomyxoviridae family of negative-sense RNA viruses. The greatest diversity of IAV strains is found in aquatic birds, but a subset of strains infects other avian as well as mammalian species, including humans. In aquatic birds, infection is largely restricted to the gastrointestinal tract and spread is through feces, while in humans and other mammals, respiratory epithelial cells are the primary sites supporting productive replication and transmission. IAV triggers the death of most cell types in which it replicate...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Contributors : John S Tregoning ; January Weiner 3rdSeries Type : Expression profiling by arrayOrganism : Mus musculusVaccination in pregnancy is an effective tool to protect both the mother and infant. Vaccines against tetanus, pertussis and influenza are recommended for use in pregnancy and new vaccines with specific indications for pregnancy are in the clinical trials pipeline. However our understanding of the immune response to vaccination in pregnancy is incomplete. We compared the effect of pregnancy on early (24 hours) transcriptional responses to vaccination. Pregnant mice and women were immunised with Boostrix-IPV...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
In conclusion, children younger than 5 years, especially boys, were vulnerable groups for pandemic influenza, presenting as a mild disease with low mortality and few complications. Most of the affected children with influenza did not have important risk factors such as asthma and obesity, highlighted by other authors as significant risk factors. PMID: 31969753 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
FRIDAY, Jan. 24, 2020 -- Many U.S. adults are misinformed about the influenza virus and the importance of flu vaccination, according to the results of a survey released by the American Academy of Family Physicians (AAFP). Wakefield Research...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.9b00620
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Publication date: Available online 23 January 2020Source: Heart &LungAuthor(s): Titilope Olanipekun, Valery S. Effoe, Olalekan Olanipekun, Efehi Igbinomwanhia, Onaopepo Kola-Kehinde, Claudia Fotzeu, Nicolas Bakinde, Rachael HarrisAbstractBackgroundEvidence suggests that annual influenza vaccination may prevent acute heart failure exacerbation episodes and improve survival.ObjectiveDetermine the influenza vaccination rate among African American patients with heart failure and identify predictors of uptake.MethodsAfrican American patients with heart failure were recruited at Grady Memorial Hospital, Atlanta GA between Oc...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host cellular antiviral response. NS1 accomplishes this role through numerous interactions with host proteins, including the cytoplasmic pathogen recognition receptor, retinoic acid–inducible gene I (RIG-I). Although the consequences of this interaction have been studied, the complete mechanism by which NS1 antagonizes RIG-I signaling remains unclear. We demonstrated previously that the NS1 RNA-binding domain (NS1RBD) interacts directly with the second caspase activation and recruitment domain (CARD) of RIG-I. We also identified t...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Microbiology Source Type: research
Abstract Infants are at increased risk for pertussis-associated morbidity and mortality, and pregnant women and their infants are more likely than other patient populations to experience severe influenza-related illness (1,2). The Advisory Committee on Immunization Practices (ACIP) recommends that all women receive the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine during each pregnancy, preferably during the early part of gestational weeks 27-36 (3). ACIP also recommends that women who are or might be pregnant during the influenza season receive the inactivated influenza vaccine...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
BOSTON (CBS) – A teenager from Worcester County has died from the flu. State health officials say it is the first influenza-associated pediatric death of this flu season in the state. The child tested positive for Influenza B. The Department of Public Health is urging people who have not received a flu shot to get vaccinated. “This is a tragic reminder of how serious the flu can be for both children and adults,” said Public Health Commissioner Monica Bharel. “Every flu season is different, but January and February are typically the height of flu season. We want people to know that it’s not t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Flu Worcester news Source Type: news
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