Polyclonal Localized Light Chain Amyloidosis —A Distinct Entity?

Amyloidosis is a rare disease of protein misfolding that results in the deposition of insoluble fibrils mainly in the extracellular spaces of tissues and organs. Currently,> 30 distinct proteins are known to cause amyloidosis in humans.1 Any organ can be involved, although the most clinically relevant are the heart, kidneys, nerves, liver, and gastrointestinal tract.2 Amyloid deposition can be systemic with involvement of multiple organs (eg, monoclonal immunoglobulin light chain amyloidosis [AL]) or can be diffuse involvement of an organ such as the kidneys (eg, lysozyme variants).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research