Petchiethers A and B, novel meroterpenoids with a 14- or 15-membered ring from Ganoderma petchii

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Cheng-Gang Li, Qi Luo, Ping-Xia Guo, Li-Li Chen, Yong-Xian Cheng Petchiethers A (1) and B (2), two novel meroterpenoids respectively with a 14- or 15-membered ring were isolated from the fruiting bodies of Ganoderma petchii. Their structures were identified by spectroscopic data. The absolute configurations of compounds 1 and 2 were assigned by computational methods. In particular, the stereochemistry of 1 was further confirmed by the Mosher’s method. The inhibitory effects of compounds 1 and 2 on fibronectin secretion were evaluated by using the ELISA technique in TGF-β1-induced rat kidney tubular epithelial cells. The results show that these substances could inhibit fibronectin production in a dose-dependent manner, indicating their potential on kidney protection. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research