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Entrepreneur with GSK roots targets lung transplant survival rates with UNC technology

In a tiny lab in Chapel Hill, a 3-year-old startup with UNC-Chapel Hill technology is trying to help lung transplant patients defy the odds. Each year, about 2,000 people receive lung transplants. And the five-year survival rate for those patients is just over half, according to the National Heart, Lung and Blood Institute. Renovion CEO Dan Copeland says a product being developed in Chapel Hill could fight that statistic. “We want t o be the first drug to be FDA approved for lung transplant patients,”…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
650,000 renal, hepatic, and cardiothoracic (heart and/or lung) transplants have been performed in the U.S. since 1988, with UNOS reporting a 20% increase in transplants between 2012 through 2016. The immunosuppression vital to maintaining graft survival comes with a 65-200X greater frequency of SCC compared to the non-transplant population. These SCC exhibit more aggressive behavior, withincreased morbidity and mortality. The aim of this study was to investigate the impact of rejection on the incidence and presentation of SCC.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Organs donated from people infected with hepatitis C can be safely transplanted, and any transmission of the virus can be treated with antiretrovirals, new research shows.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Transplantation News Source Type: news
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
In his book, The Checklist Manifesto: How to Get Things Right, Atul Gawande describes the origins of the checklist that involved the airline industry beginnings of the B-17 airplane.1 The test plane ’s flight ended in a deadly crash deemed due to pilot error. The B-17 was felt to be too much plane for one pilot and was abandoned as the next generation long-range bomber for the U.S. military. A persistent group of pilots developed a checklist of tasks to be performed for each phase of flight t ake-off, inflight, and landing.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
ConclusionsTranscatheter LA decompression is an age-independent, effective palliation treating patients with HFpEF.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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