Entrepreneur with GSK roots targets lung transplant survival rates with UNC technology

In a tiny lab in Chapel Hill, a 3-year-old startup with UNC-Chapel Hill technology is trying to help lung transplant patients defy the odds. Each year, about 2,000 people receive lung transplants. And the five-year survival rate for those patients is just over half, according to the National Heart, Lung and Blood Institute. Renovion CEO Dan Copeland says a product being developed in Chapel Hill could fight that statistic. “We want t o be the first drug to be FDA approved for lung transplant patients,”…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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AbstractPurpose of ReviewFactors such as weight, body composition, and functional status appear to influence lung transplant outcomes. Body mass index (BMI) is incorporated into the International Society for Heart and Lung Transplantation ’s (ISHLT) recipient selection guidelines. Data suggests BMI does not effectively differentiate patients with high body fat percentage or low lean muscle mass, leading to both over and under estimates of candidates’ risks.Recent FindingsRecent research has focused on alternate measures and estimates of body composition and their associations with important lung transplant outc...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Purpose of review The current review highlights the most relevant articles on lung infections following hematopoietic stem cell transplantation (HCT) published over the last year. Between 30 and 50% of HCT recipients will develop pulmonary infiltrates. These pulmonary complications may be infectious (caused by virus, bacteria, fungi, or protozoa) or noninfectious (e.g., fluid overload, heart failure, transfusion reactions like transfusion associated lung injury and transfusion-associated circulatory overload, drug reactions, engraftment syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, cryptogenic org...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: INFECTIOUS COMPLICATIONS IN TRANSPLANTATION: Edited by Shimon Kusne Source Type: research
Medtronic has gained FDA approval for a less-invasive implant approach of its HVAD System, a left ventricular assist device (LVAD) for advanced heart failure patients. The Dublin-based company picked up the technology when it acquired HeartWare in 2016. The firm said the technology is the only LVAD approved in the U.S. for implant via thoracotomy, a small lateral, surgical incision between the patient's ribs on the left side of the chest. FDA approval for HVAD implantation via thoracotomy is based on data from the LATERAL prospective clinical trial, in which 144 patients, with end-stage heart failure who were eligible for ...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Business Source Type: news
ConclusionsOur analysis does not confirm previously reported associations between traffic-related air pollution exposure and the risk of transplant failure.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Publication date: June 2018Source: Anaesthesia &Intensive Care Medicine, Volume 19, Issue 6Author(s): Barbora Parizkova, Gavin WrightAbstractThe Registry of the International Society for Heart and Lung Transplantation reported 4196 heart transplants and 3812 lung transplants worldwide in 2015. The 100,000th heart transplant mark has been passed. Heart transplantation is a proven surgical option for selected patients who have advanced heart failure refractory to surgical or medical management. Lung transplantation is the definitive treatment for end-stage lung disease for patients who have failed medical therapy. More t...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
ConclusionsECMO as BTT has led to encouraging perioperative outcomes and early survival. Careful patient selection and early use of ECMO seems to allow for preservation of vitality while these critically ill candidates await donor organs, which may improve outcomes.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
AbstractPurpose of ReviewThe first human lung transplant surgery in the world was done in 1963, followed by the first heart transplant in 1967, making this year its 50th anniversary. Since then, there has been great advancement in immunotherapy, with the adoption of calcineurin inhibitors (CNI), mycophenolate mofetil, and proliferation signal inhibitors (PSI). However, while these medications are crucial to maintenance of allograft function and prevention of allograft rejection, they have many toxicities and side effects, which make therapeutic dose monitoring and recognition of drug-drug interactions of critical importanc...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsOur analysis does not confirm previously reported associations between traffic-related air pollution exposure and the risk of transplant failure.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Publication date: June 2018Source: Anaesthesia &Intensive Care Medicine, Volume 19, Issue 6Author(s): Barbora Parizkova, Gavin WrightAbstractThe Registry of the International Society for Heart and Lung Transplantation reported 4196 heart transplants and 3812 lung transplants worldwide in 2015. The 100,000th heart transplant mark has been passed. Heart transplantation is a proven surgical option for selected patients who have advanced heart failure refractory to surgical or medical management. Lung transplantation is the definitive treatment for end-stage lung disease for patients who have failed medical therapy. More t...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
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