Proton therapy demand wave drives expansion of Belgium ’ s IBA

(Reuters) – When Yves Jongen stood at the controls of his proton therapy machine 15 years ago to treat a cancer patient for the first time he was petrified. Now Jongen’s company IBA is hiring 400 engineers to cope with demand for the technology, increasing its workforce by a third, and expanding its production capacity to make up to 30 machines a year, from a maximum of 8 now. “It is such a responsibility to send a beam of potentially lethal particles into the body of a fellow human being. It is exciting but scary at the same time,” he said. Proton therapy made the front pages in Britain last year when 5-year-old Ashya King was removed from hospital by his parents, against the advice of doctors, and flown to Prague for treatment using an IBA-made machine. There are only 170 proton therapy treatment rooms worldwide to handle about 1% of radiation therapy patients. But there is already a consensus on the technology’s benefits for certain types of patients, such as children and young adults with spinal cord and base of brain tumours and a growing belief that it could also limit side effects. King’s family say he is now free of cancer. A spin-off of the Catholic University of Louvain’s nuclear physics department, IBA began life making cyclotrons to produce radioisotopes for hospitals and radiopharmaceutical companies. “We would sell one machine a year and enjoy ourselves a lot doing it,” said Jongen, 68, who founded ...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Business/Financial News Radiosurgery IBA Source Type: news

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Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
In conclusion, CD133 promoted the upregulation of CSC/TSC-related genes in glioma cells, while enhancing the neurosphere-forming ability and in-vivo oncogenicity. PMID: 30891998 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
In this study, several cerasome-forming lipoamino acids (CFLA) were synthesized and used as structural blocks for cerasome preparation. Pure cerasomes which contained only CFLA, and mixed cerasomes based on a mixture of CFLA with a disintegrating dipalmitoylphosphatidylcholine (DPPC) lipid were fabricated and characterized in terms of morphology, mean size, ζ-potential, stability at storage. All obtained cerasome samples were found to be much more stable at storage than conventional liposomes (120 and 10 days, respectively). The cerasomes were loaded with doxorubicin (DOX) and tested in vitro using human breast aden...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Taxol is a common chemotherapy (CTX) drug that is associated with the development of neuropathy. Paclitaxel-induced peripheral neuropathy (PIPN) is the dose limiting toxicity of this CTX drug. Paclitaxel exerts its therapeutic effect by binding to β-tubulin, which interferes with microtubule dynamics and results in microtubule stabilization, mitotic arrest, and apoptosis of cancer cells. However, microtubules are critical for axonal function and for the transport of essential organelles to distal nerve endings.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
The objectives of this work were to study 1) effects of oxaliplatin on membrane excitability in Isoletcin B4-positive and –negative (IB4+ and IB4-) subpopulations of dorsal root ganglion (DRG), and 2) targeting oxaliplatin-induced membrane hyperexcitability to relief neuropathic pain.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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