Proton therapy demand wave drives expansion of Belgium ’ s IBA
(Reuters) – When Yves Jongen stood at the controls of his proton therapy machine 15 years ago to treat a cancer patient for the first time he was petrified. Now Jongen’s company IBA is hiring 400 engineers to cope with demand for the technology, increasing its workforce by a third, and expanding its production capacity to make up to 30 machines a year, from a maximum of 8 now. “It is such a responsibility to send a beam of potentially lethal particles into the body of a fellow human being. It is exciting but scary at the same time,” he said. Proton therapy made the front pages in Britain last year when 5-year-old Ashya King was removed from hospital by his parents, against the advice of doctors, and flown to Prague for treatment using an IBA-made machine. There are only 170 proton therapy treatment rooms worldwide to handle about 1% of radiation therapy patients. But there is already a consensus on the technology’s benefits for certain types of patients, such as children and young adults with spinal cord and base of brain tumours and a growing belief that it could also limit side effects. King’s family say he is now free of cancer. A spin-off of the Catholic University of Louvain’s nuclear physics department, IBA began life making cyclotrons to produce radioisotopes for hospitals and radiopharmaceutical companies. “We would sell one machine a year and enjoy ourselves a lot doing it,” said Jongen, 68, who founded ...
Authors: Li T, Han J, Jia L, Hu X, Chen L, Wang Y Abstract A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by p...
In conclusion, CD133 promoted the upregulation of CSC/TSC-related genes in glioma cells, while enhancing the neurosphere-forming ability and in-vivo oncogenicity. PMID: 30891998 [PubMed - as supplied by publisher]
In this study, several cerasome-forming lipoamino acids (CFLA) were synthesized and used as structural blocks for cerasome preparation. Pure cerasomes which contained only CFLA, and mixed cerasomes based on a mixture of CFLA with a disintegrating dipalmitoylphosphatidylcholine (DPPC) lipid were fabricated and characterized in terms of morphology, mean size, ζ-potential, stability at storage. All obtained cerasome samples were found to be much more stable at storage than conventional liposomes (120 and 10 days, respectively). The cerasomes were loaded with doxorubicin (DOX) and tested in vitro using human breast aden...
In this study, a sustaining antifouling membrane was fabricated by constructing polydopamine (PDA) micro-/nano-spheres on a polyacrylonitrile (PAN) nanofibrous membrane. The secondary PDA nano-spheres not only strengthened the bonding of primary micro-spheres with the substrate, but also diversified the hierarchical structure and chemistry. The composite showed enhanced superhydrophilicity and underwater superoleophobicity. Permeability of PAN-PDAc membrane was maintained as high as 11666 ± 978 Lm−2h−1bar−1 with separation efficiency of higher than 99.9% over a 2-h continuous filtration. This...
Taxol is a common chemotherapy (CTX) drug that is associated with the development of neuropathy. Paclitaxel-induced peripheral neuropathy (PIPN) is the dose limiting toxicity of this CTX drug. Paclitaxel exerts its therapeutic effect by binding to β-tubulin, which interferes with microtubule dynamics and results in microtubule stabilization, mitotic arrest, and apoptosis of cancer cells. However, microtubules are critical for axonal function and for the transport of essential organelles to distal nerve endings.
The objectives of this work were to study 1) effects of oxaliplatin on membrane excitability in Isoletcin B4-positive and –negative (IB4+ and IB4-) subpopulations of dorsal root ganglion (DRG), and 2) targeting oxaliplatin-induced membrane hyperexcitability to relief neuropathic pain.
Tongue cancer patients suffer severe, chronic pain driven by oral cancer-induced activation of sensory neurons innervating the oral cavity. However, the impact of sensory neurotransmission on oral carcinogenesis is understudied. Local neurotransmitter release from sensory neurons innervating the cancer has been linked to cancer growth and immune suppression. We hypothesize that oral cancer-induced neurotransmitter release from trigeminal sensory neurons (TGNs) promotes oral cancer proliferation and suppresses the immune response.
The experience of cancer pain is poorly understood from the perspective of African Americans, who experience higher levels of pain, more pain-related distress, and poorer function than Caucasians. Perceived control over pain has been shown to lead to decreased pain and distress and improved functional status. Perceived control over pain may play a role in the adequacy of prescriptions received by African American patients with cancer pain. The purpose of this study is to investigate the relationship between factors affecting analgesic prescriptions and perceived control over pain in African Americans with cancer pain.
The current study assessed associations of clinical characteristics and all-cause mortality among a cohort of Veterans initiating pain services. Analyses were also stratified by age to examine potential variations. Demographic (male, age), medical comorbidities (diabetes, myocardial infarction, chronic pulmonary conditions, cancer, renal disease, liver disease), pain characteristics (pain intensity, opioid analgesic prescription), and mental health characteristics (depression, opioid use disorder, opioid poisoning/suicide attempts) were extracted from Veterans Health Administration records.
Acute postoperative pain is a predictable response and when left untreated can lead to chronic pain, prolonged rehabilitation, and other complications after breast surgery. Pectoral nerve block (PECSB) has been recently reported as an analgesic method for BCS. In recent literature, it is evident that PECSB significantly reduced intraoperative opioid usage, postoperative pain, PONV, and postoperative opioid requirements. Introduction of ultrasound in regional anesthesia practice influenced the practice and choice of blocks for any given surgery.
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