Dose-Titrated Vasopressin V2 Receptor Antagonist Improves Renoprotection in a Mouse Model for Autosomal Dominant Polycystic Kidney Disease.

CONCLUSIONS: Titration of a V2RA aimed to maintain aquaresis at a high level showed a better renoprotective effect compared to FD administration. However, this treatment regimen was poorly tolerated and did not overcome treatment unresponsiveness when started later in the disease.
PMID: 27578560 [PubMed - as supplied by publisher]

Source: American Journal of Nephrology - August 30, 2016 Category: Urology & Nephrology Authors: Zittema D, Versteeg IB, Gansevoort RT, van Goor H, de Heer E, Veraar KA, Peters DJ, Meijer E Tags: Am J Nephrol Source Type: research