SPATA2 - Keeping the TNF signal short and sweet

In this issue of The EMBO Journal, a multi-layered global proteome resource, which comprehensively covers TNF-induced phosphorylation and ubiquitination events as well as receptor interactions, has led to identification of SPATA2 as a novel player that contributes to TNF signalling by interacting with the LUBAC ubiquitin ligase and the CYLD deubiquitylase. Loss of SPATA2 augments transcriptional activation of NF-B and limits TNF-induced necroptosis. A separate screen published in EMBO Reports corroborates these findings by showing that SPATA2 deficiency regulates CYLD activity, TNF-induced NF-B signalling and cell death.

Source: EMBO Journal - August 31, 2016 Category: Molecular Biology Authors: Feltham, R., Webb, A. I., Silke, J. Tags: Immunology, Post-translational Modifications, Proteolysis & Proteomics, Signal Transduction News [amp ] Views Source Type: research