Autophagosome-lysosome fusion: PIs to the rescue

Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Autophagy & Cell Death, Membrane & Intracellular Transport, Molecular Biology of Disease News [amp ] Views Source Type: research