Abstract # 1724 Depression and inflammation are independent predictors of fatigue in breast cancer survivors

Publication date: October 2016 Source:Brain, Behavior, and Immunity, Volume 57, Supplement Author(s): C. Xiao, A. Miller, J. Felger, D. Mister, T. Liu, M. Torres The purpose of this study was to examine predictors of fatigue in breast cancer survivors one-year post-radiotherapy. This cross-sectional, observational study enrolled 111 patients treated with breast conserving surgery followed by whole breast radiotherapy. Half of the patients received chemotherapy. The primary outcome variable was fatigue, measured by the Multidimensional Fatigue Inventory-20. Predictors included inflammation, age, race, marital status, smoking history, menopause status, endocrine treatment, cancer stage, depression (Inventory of Depressive Symptomatology–Self Reported), sleep problems (Pittsburgh Sleep Quality Index), and perceived stress (Perceived Stress Scale). Inflammation was assessed by plasma cytokines and/or their receptors using Multiplex ELISA and acute phase proteins (CRP) using a standard turbidimetric assay. Linear regression was employed to examine predictors of fatigue, and a mediation model using PROCESS SPSS was conducted to examine the association between depression, sleep problems, stress, inflammation and fatigue. At one-year post-radiotherapy, depression (B =0.65, p <0.001; B =0.73, P <0.0001; B =0.71, p <0.0001, for models with CRP, interleukin-1 receptor antagonist (IL1ra), or soluble tumor necrosis factor receptor2 (sTNFR2) respectively) and...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research