Abstract # 1724 Depression and inflammation are independent predictors of fatigue in breast cancer survivors

Publication date: October 2016 Source:Brain, Behavior, and Immunity, Volume 57, Supplement Author(s): C. Xiao, A. Miller, J. Felger, D. Mister, T. Liu, M. Torres The purpose of this study was to examine predictors of fatigue in breast cancer survivors one-year post-radiotherapy. This cross-sectional, observational study enrolled 111 patients treated with breast conserving surgery followed by whole breast radiotherapy. Half of the patients received chemotherapy. The primary outcome variable was fatigue, measured by the Multidimensional Fatigue Inventory-20. Predictors included inflammation, age, race, marital status, smoking history, menopause status, endocrine treatment, cancer stage, depression (Inventory of Depressive Symptomatology–Self Reported), sleep problems (Pittsburgh Sleep Quality Index), and perceived stress (Perceived Stress Scale). Inflammation was assessed by plasma cytokines and/or their receptors using Multiplex ELISA and acute phase proteins (CRP) using a standard turbidimetric assay. Linear regression was employed to examine predictors of fatigue, and a mediation model using PROCESS SPSS was conducted to examine the association between depression, sleep problems, stress, inflammation and fatigue. At one-year post-radiotherapy, depression (B =0.65, p <0.001; B =0.73, P <0.0001; B =0.71, p <0.0001, for models with CRP, interleukin-1 receptor antagonist (IL1ra), or soluble tumor necrosis factor receptor2 (sTNFR2) respectively) and inflammation (...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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Authors: Dome P, Faludi G Abstract Main indications of antidepressants (ADs) as major depressive disorder (MDD) and different kinds of anxiety disorders are quite prevalent during pregnancy and the postpartum period. Due to the possible hazards of in utero and breast milk exposition of ADs, both psychiatrists and mothers frequently have concerns about the use of ADs during the periods of pregnancy and breastfeeding. However, we should also bear in mind that affective disorders left untreated during these periods are also associated with health risks for the mother and the baby as well. Accordingly, the treatment of...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
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Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
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Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Authors: van Dalfsen JH, Markus CR Abstract The short (S) allele of a functional polymorphism (5-HTTLPR) within the promoter region of the serotonin transporter gene (SLC6A4) is found to predispose the risk for stress-related affective disorders relative to the long (L) allele. Evidence suggests that elevated stress reactivity of the hypothalamic-pituitary-adrenal (HPA) axis might underlie this association although there is little understanding about the origin of inconsistent findings. Since inadequate sleep is commonly known to promote HPA stress reactivity, it might well play an important modulating role. The pr...
Source: Stress - Category: Research Tags: Stress Source Type: research
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Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
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Source: Journal of Palliative Care - Category: Palliative Care Tags: J Palliat Care Source Type: research
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Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
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Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
The World Cancer Research Fund (WCRF) has bad news for lovers of bacon and booze: Eliminating processed meats and alcohol from your diet may help reduce your risk of developing cancer. The third report from the WCRF’s Continuous Update Project, an ongoing effort to inform consumers about lifestyle habits that may be related to cancer, provides numerous recommendations for people looking to minimize their risk of getting cancer. But two, in particular, are likely to cause a stir for many Americans. First, the WCRF recommends significantly or totally cutting back on processed meats including bacon, salami, hot dogs and...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer healthytime onetime Source Type: news
Contributors : Duhen Thomas ; Montler Ryan ; Weinberg AndrewSeries Type : Expression profiling by arrayOrganism : Homo sapiensIdentifying tumor antigen-specific T cells from cancer patients has been a goal of tumor immunologists for several decades. Co-expression of CD103 and CD39 on CD8 TIL highly enriches for tumor-reactive T cells. CD39+CD103+ CD8 TIL have a distinct TCR repertoire compared to other CD8 TIL subsets and are clonally expanded within the tumor.They are highly enriched for tumor antigen recognition and efficiently killed autologous tumor cells. Patients with head and neck cancer whose CD8 TIL contained a hi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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