Axon pathology and repair

Publication date: October 2016 Source:Journal of Chemical Neuroanatomy, Volume 76, Part A Author(s): Anna King, Alison Canty
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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CONCLUSIONS: LncRNA LINC00707 promoted osteogenic differentiation of hBMSCs by targeting LRP5 mediated by miR-145 through the activation of the Wnt/β-catenin pathway. PMID: 31957814 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 21 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Takashi Hoshiba, Natsumi YokoyamaAbstractThe regulation of stem cell differentiation is key for muscle tissue engineering and regenerative medicine. To this end, various substrates mimicking the native extracellular matrix (ECM) have been developed with consideration of the mechanical, topological, and biochemical properties. However, mimicking the biochemical properties of the native ECM is difficult due to its compositional complexity. To develop substrates that mimic the native ECM and its bi...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Publication date: 15 February 2020Source: Life Sciences, Volume 243Author(s): Karine Cestaro Mesquita, Thinali Sousa Dantas, Paulo Goberlânio de Barros Silva, Maria Imaculada de Queiroz Rodrigues, Ana Paula Negreiros Nunes Alves, Mário Rogério Lima Mota, Fabrício Bitu SousaAbstractThe present study aimed to evaluate the healing process of ulcers in the jugal mucosa of Wistar rats treated with abatacept. The rats were randomly assigned to four groups: saline-treated control (0.3 mL/kg) abatacept-treated groups at dosages of 3.2, 8.0 and 20.0 mg/kg/week. After two weeks of subcutaneous (S...
Source: Life Sciences - Category: Biology Source Type: research
Conclusion and relevance: Patients in this series with chronic MH who underwent no-face-down MH repair demonstrated a high single-surgery anatomical closure rate with a significant improvement in visual acuity.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Purpose: To quantify changes in photoreceptor density using adaptive optics fundus camera in patients after retinal detachment (RD) and to correlate them with macular involvement and best-corrected visual acuity. Methods: At 1 and 3 months (M1 and M3) after vitrectomy, 194 patients underwent adaptive optics imagery in both eyes, at 5 locations, that we matched between time points using anatomical landmarks. Twenty-two patients (10 fovea-OFF [OFF] and 12 fovea-ON [ON]) had matched and analyzable adaptive optics images. We used analysis of variance for repeated measures. Results: Best-corrected visual acuity (logarit...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Delivery of exosomes derived from stem cell populations has been demonstrated to improve recovery from injury in numerous studies and human applications. The interesting aspect of this demonstration in stroke recovery in pigs is that exosomes from neural stem cells provoke greater functional recovery without improving some of the structural changes that are normally associated with greater mortality and loss of function. Researchers have presented brain imaging data for a new stroke treatment that supported full recovery in swine, modeled with the same pattern of neurodegeneration as seen in humans with severe str...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Megan, from Florida, was bullied so much at school that her mother agreed to pay for cosmetic surgery but two operations went wrong and she has lived with the damage for decades.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, mouse pulmonary stem/progenitor cells (mPSCs) with capability to differentiate into type I or type II alveolar cells were used as an in vitro cell model to characterize replication and pathogenic effects of influenza viruses in PSCs. First, mPSCs and its immortalized cell line mPSCsOct4+ were shown to be susceptible to PR8, seasonal H1N1, 2009 pandemic H1N1, and H7N9 influenza viruses and can generate infectious virus particles, although with a lower virus titer, which could be attributed by the reduced vRNA replication and nucleoprotein (NP) aggregation in the cytoplasm. Nevertheless, a significant increase...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions: The in vitro results on the beneficial effects of TVE on tissue elasticity and regeneration may support a better understanding of the action mechanism of TVE as active principles in pharmaceutical preparation in wound treatment.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Achieving replicative immortality is a crucial step in tumorigenesis and requires both bypassing cell cycle checkpoints and the extension of telomeres, sequences that protect the distal ends of chromosomes during replication. In the majority of cancers this is achieved through the enzyme telomerase, however a subset of cancers instead utilize a telomerase-independent mechanism of telomere elongation—the Alternative Lengthening of Telomeres (ALT) pathway. Recent work has aimed to decipher the exact mechanism that underlies this pathway. To this end, this pathway has now been shown to extend telomeres through exploitat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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