Variation in 'junk' DNA leads to trouble

(Duke University) Although genetic variants are scattered throughout the human genome, scientists have largely ignored the stretches of repetitive genetic code known as 'junk' DNA in their search for differences that influence human health and disease. Now, Duke researchers have discovered that variation in these overlooked regions can affect the stability of the genome and the proper function of the chromosomes that package our genetic material, leading to an increased risk of birth defects, infertility, and cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Contributors : Naoki Uyama ; Xian-Yang Qin ; Soichi Kojima ; Jiro FujimotoSeries Type : Expression profiling by arrayOrganism : Mus musculusAbdominal adhesions form in response to peritoneal trauma that can occur during surgery. Postoperative adhesions, which develop in approximately 50-85% of patients who have undergone abdominal surgery, often result in severe complications, including intestinal obstruction, female infertility, chronic pain, and contraindication of surgery for future abdominal illnesses such as cancer. Here, we investigated the cell source of collagen production in postoperative adhesions and explored mo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
It continues to happen: I run into people who say to me “I follow the Wheat Belly lifestyle. I eat gluten-free!” When I ask them what that means, they tell me that they only eat gluten-free bread, pasta, pizza, cookies, etc. I’m not entirely sure why this misinterpretation of the Wheat Belly message is so common. Let’s talk about this important distinction, as being gluten-free can be an absolute health and weight disaster, unlike the magnificent health and weight loss we enjoy on the Wheat Belly lifestyle when done right. It’s perfectly fine to be gluten-free, i.e., avoiding wheat, rye, and b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune blood sugar gluten gluten-free grain grain-free grains Weight Loss wheat belly Source Type: blogs
Hodgkin Lymphoma (HL) is a chemo-radiosensitive cancer with a five-year survival rate over 85% with current therapies [1]. However, there are serious long-term therapy related adverse events such as second cancers, cardiac and peripheral vascular disease, pulmonary disease, infertility, sexual dysfunction, etc. Therefore, it is extremely important to reduce the long-term side effects, reducing the amount and toxicity of poly-chemotherapies and improving staging procedures [2,3].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research
The world’s first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet. Uterus transplants have become more common in recent years, resulting in 11 live births around the world. But all of the other successful deliveries so far have been made possible by living donors — often women who opt to donate their uterus to a close friend or family member without one. The birth resulting from the case detailed in the Lancet, which took place at Brazil’s Hospital das Clínicas last December, is both the first...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility healthytime Source Type: news
ConclusionThese results suggested the herbal decoctions promoted the fertilization of mice, which was related to the charge of PI3K/Akt activation.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Authors: Badria FA, Suliman SN, Elsbaey M, El-Naggar MH Abstract Iron overload is implicated in many disorders in the body such as heart failure, liver cirrhosis and fibrosis, gallbladder disorders, diabetes, arthritis, depression, infertility, and cancer. Even though synthetic chelating agents are available, they have several limitations such as poor oral bioavailability, short plasma half-life, high cost and numerous side effects. Therefore, the aim of this study is using agricultural residues as sources for alternative efficient, benign, and economic iron chelators of natural origin. Eighteen agricultural residu...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
AbstractObjectiveCancer patients experience reproductive concerns from diagnosis through to survivorship. However, research has yet to investigate the degree of fertility ‐related psychological distress at different treatment time points: diagnosis, treatment, and survivorship. Currently, cancer patients are offered fertility counselling at the time of diagnosis, to assist fertility preservation decision making. A systematic review of the short‐term and long‐te rm psychological impact of infertility in cancer patients would inform on an improved, longitudinal model of psychological care.MethodsA systematic review of ...
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
There is a large body of evidence showing that n ‐3 polyunsaturated fatty acids (PUFAs) have benefits on general health. This review discusses molecular mechanisms by which n‐3 PUFAs affect oocyte maturation and developmental competence. Infertility is a growing problem worldwide. Currently, in vitro fertilization (IVF) is widely performed to treat infertility. However, a high percentage of IVF cycles fails, due to the poor developmental potential of the retrieved oocyte to generate viable embryos. Fatty acid content of the follicular microenvironment can affect oocyte maturation and the subsequent developmental compet...
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: MINI REVIEW Source Type: research
Constitutional (germline) chromosomal rearrangements, including translocations and inversions, are well recognized for their potential to impact fertility and miscarriage risk [1,2]. Conventional chromosome studies are routinely performed on adult patients with histories of infertility or recurrent miscarriages, and it is under these circumstances when constitutional rearrangements are often revealed [1,2]. However, in this context, carriers of constitutional rearrangements are often phenotypically and cognitively normal (assuming the rearrangements are truly balanced and genes of clinical significance are intact) and thes...
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
This article mainly opted advance nanotherapy methods, based on most recent studies. Result and conclusion- Nanotechnology provides new molecular contrasts agents and materials to enable earlier and more accurate initial diagnosis, as well as continual monitoring of patient while cancer treatment. This review concludes that nanotechnology as nanodrugs, nano carrier, nanoparticles in combination with radiological methods have a better future in cancer treatment. In this paper, several diagrammatic pathways presented the opted studies and proposed conclusion. PMID: 30426890 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
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