Variation in 'junk' DNA leads to trouble

(Duke University) Although genetic variants are scattered throughout the human genome, scientists have largely ignored the stretches of repetitive genetic code known as 'junk' DNA in their search for differences that influence human health and disease. Now, Duke researchers have discovered that variation in these overlooked regions can affect the stability of the genome and the proper function of the chromosomes that package our genetic material, leading to an increased risk of birth defects, infertility, and cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Young boys are often left infertile after childhood cancer treatment, with no way of preserving their sperm. Now, new research might allow them to father children.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Researchers have figured out how to grow human stem cells to help children treated for cancer who become infertile later in life.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
(Natural News) Conventional treatments for cancer, such as chemotherapy and radiation, are known for targeting even healthy cells. The damage induced on healthy cells by non-selective targeting these cancer treatments lead to side effects like diarrhea, anemia, infertility, mood changes, and weight loss. To avoid these side effects, people are now turning to traditional medicine...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
asmüller S Abstract Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis extracts, as they prevent epilepsy, anxiety, and seizures. It was claimed that they may be useful in cancer therapy and have anti-inflammatory properties. Adverse long-term effects of these drugs (induction of cancer and infertility) which are related to damage of the genetic material have not been investigated. Therefore, we studied their DNA-damaging properties in human-derived cell lines under conditions which reflect the exposure of consumers. Both compoun...
Source: Archives of Toxicology - Category: Toxicology Authors: Tags: Arch Toxicol Source Type: research
Treatment for cancer and other serious conditions involves toxic chemotherapy drugs, radiation and surgery that can cause infertility in women and men.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
There is no acceptable scientific evidence that chiropractors can treat Alzheimer's disease, cancer, diabetes, infertility, infections, autism, ADHD or Down syndrome. And yet, some practitioners in this province claim they can.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
Discussion Cryptorchidism is the failure of one or both testes to descend from the abdomen into the scrotum. Congenital undescended testis (UDT)is common in young infants (1-4% in term infants and 45% in preterm infants) in that the testes will be palpable but remain high, but most testes will descend by 3-6 months and by 9 months of age only 1% remain undescended. The scrotum often appears underdeveloped. Sometimes the testes cannot be identified and is intra-abdominal at birth. Intra-abdominal testes are less likely to migrate to the scrotum and therefore are more likely to remain undescended. Acquired undescended test...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Scientists may soon be able to create human sperm and eggs using ordinary cells – a boon for those with fertility problems that raises troubling ethical questionsForty years ago, couples suffering from infertility were given hope by the birth of Louise Brown, the first “test-tube baby”. But although millions of babies have now been born by IVF, the technique can offer no help to couples eager to have a child that is genetically theirs but who lack the eggs or sperm to make it: men whose testes produce no sperm, say, or women who have undergone surgery for ovar ian cancer. Some opt for donor eggs or sperm,...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Reproduction Fertility problems IVF Biology Science Health Society Source Type: news
Publication date: Available online 10 October 2018Source: Trends in GeneticsAuthor(s): Aaron C. Goldstrohm, Traci M. Tanaka Hall, Katherine M. McKenneyMammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory networks, biological functions, and relevance to diseases. Pumilio proteins bind an extensive network of mRNAs and repress protein expression by inhibiting translation and promoting mRNA decay. Opposingly, in certain contexts, they can activate protein expression. Pumilio proteins also regulate noncoding (...
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research
Researchers from Harvard found that '3-Free' polishes that claim to be free of the 'toxic trio' - DnBP, toluene and formaldehyde - often still contain toxins linked to brain toxicity and even foetal abnormalities.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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