How much do Medicine students know about Chagas' disease in Spain?

[How much do Medicine students know about Chagas' disease in Spain?] Gac Sanit. 2016 Aug 24; Authors: Ramos JM, Martorell C, López-Amorós AI, Navarro M PMID: 27568170 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: Global & Universal Tags: Gac Sanit Source Type: research

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Triatoma brasiliensis Neiva, 1911 and Triatoma pseudomaculata Corrêa and Espínola, 1964 (Hemiptera, Reduviidae, Triatominae) in rural communities in Northeast Brazil. Rev Inst Med Trop Sao Paulo. 2020;62:e74 Authors: Ferreira ALDS, Santana MA, Santos LVBD, Monteiro DP, Campos JHF, Sena LLJ, Mendonça VJ Abstract Chagas disease is an important endemic morbidity in Latin America affecting millions of people in the American continent. It is caused by the protozoan Trypanosoma cruzi, and transmitted through the feces of the insect vector belonging to the subfamily Triatominae. The prese...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Chagas disease is a zoonotic infection caused by the parasite Trypanosoma cruzi, which affects an estimated 8 –11 million people globally. Chagas disease is almost always associated with poverty in rural areas and...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the efforts to control the vector throughout the Americas, currently, there are almost seven million infected people worldwide, causing ~10,000 deaths per year, and 70 million people at risk to acquire the infection. Chagas disease treatment is restricted only to two parasiticidal drugs, benznidazole and nifurtimox, which are effective during the acute and early infections but have not been found to be as effect...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of Leishmania amazonensis and the epimastigote form of Trypanosoma cruzi, the pathogens causing the neglected tropical diseases leishmaniasis and Chagas disease, respectively. The results show the potential of these compounds regarding their antiparasitic properties. Studies on the structure-activity relationship demonstrated that compounds containing a bulky group at the para pos...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
iro M Abstract Quinolines are nitrogen heterocyclic compounds ubiquitous in nature and largely used as a structural component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological properties, acting as antimalarial drugs, antiparasitic, antibacterial, antiviral, antifungal, and anticancer agents, besides being in clinical use for autoimmune diseases. Presently, a brief review is present regarding the biological effect and clinical use of quinolines and derivatives up...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
ntino de Sousa Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical co...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
by Isabel S. Shiratsubaki, Xin Fang, Rodolpho O. O. Souza, Bernhard O. Palsson, Ariel M. Silber, Jair L. Siqueira-Neto Chagas disease is a neglected tropical disease and a leading cause of heart failure in Latin America caused by a protozoan calledTrypanosoma cruzi. This parasite presents a complex multi-stage life cycle. Anti-Chagas drugs currently available are limited to benznidazole and nifurtimox, both with severe side effects. Thus, there is a need for alternative and more efficient drugs. Genome-scale metabolic models (GEMs) can accurately predict metabolic capabilities and aid in drug discovery in metabolic genes....
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
JLR Abstract ENTPDases are enzymes known for hydrolyzing extracellular nucleotides and playing an essential role in controlling the nucleotide signaling via nucleotide/purinergic receptors P2. Moreover, ENTPDases, together with Ecto-5´-nucleotidase activity, affect the adenosine signaling via P1 receptors. These signals control many biological processes, including the immune system. In this context, ATP is considered as a trigger to inflammatory signaling, while adenosine (Ado) induces anti-inflammatory response. The trypanosomatids Leishmania and Trypanosoma cruzi, pathogenic agents of Leishmaniasis and Ch...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Abstract Rhodnius prolixus is an obligatorily hematophagous insect known as an important vector of Chagas disease. Autophagy is a conserved cellular mechanism that acts in response to nutrient starvation, where components of the cytoplasm are sequestered by a double membrane organelle, named autophagosome, which is targeted to fuse with the lysosome for degradation. Lipophagy is the process of lipid degradation by selective autophagy, where autophagosomes sequester lipid droplets and degrade triacylglycerol (TAG) generating free fatty acids for β-oxidation. Here, two essential genes of the autophagic pathway,...
Source: Insect Biochemistry and Molecular Biology - Category: Biochemistry Authors: Tags: Insect Biochem Mol Biol Source Type: research
by Peter Hotez, Maria Elena Bottazzi, Nathalie Strub-Wourgaft, Sergio Sosa-Estani, Faustino Torrico, Leire Paj ín, Marcelo Abril, Javier Sancho
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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