Fingerprints Disappear During Capecitabine Therapy Fingerprints Disappear During Capecitabine Therapy
The commonly used chemotherapy agent capecitabine can leave many patients without fingerprints, but the effect is temporary.Medscape Medical News
We describe a case of an 80-year-old woman with ovarian metastasis of MCC six years after excision of a cutaneous MCC on the cheek.DiscussionTo our knowledge only three cases with ovarian metastasis of MCC have been described so far. Our case is the second with distant metastasis to the ovary spreading from a primary tumor in the skin of the head, in the other two cases the primary tumor was in the inguinal skin.ConculsionMCC is a highly aggressive cutaneous and mucosal malignancy with frequent recurrence, lymph node and distant metastases. There is no clear consensus how to treat metastatic disease.
(MedPage Today) -- Survival at 2 years was 72.4% versus 40.9% with chemotherapy alone
Abstract Chemotherapy-induced premature ovarian insufficiency (POI) is one of the potential drawbacks of chemotherapy use of particular concern for newly diagnosed premenopausal breast cancer patients. Temporary ovarian suppression obtained pharmacologically with the administration of a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been specifically developed as a method to counteract chemotherapy-induced gonadotoxicity with the main goal of diminishing the risk of POI. In recent years, important clinical evidence has become available on the efficacy and safety of this strategy that should...
Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. However, atypical cases that lack monoclonal gammopathy and that present with hypothyroidism have been rep...
Conclusion: The atypical presentation of gallbladder metastases could mislead treating providers. The diagnosis might alter management decisions and prognosis.Case Rep Oncol 2019;12:235 –240
Publication date: Available online 19 March 2019Source: Journal of Bone OncologyAuthor(s): Alexandros Stamatopoulos, Theodosios Stamatopoulos, Zakareya Gamie, Eustathios Kenanidis, Ricardo Da Conceicao Ribeiro, Kenneth Samora Rankin, Craig Gerrand, Kenneth Dalgarno, Eleftherios TsiridisAbstractOver the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined w...
Artificial intelligence (AI) and radiomics can identify which non-small cell...Read more on AuntMinnie.comRelated Reading: AI may predict lymph node metastasis in gastric cancer AI singles out high-risk prostate cancer on mpMRI AI can predict breast cancer molecular subtypes on MRI AI can differentiate glioblastoma, brain metastasis AI uses features outside nodules to predict malignancy
Conclusion: Our study obtained several DEG expressions and signaling pathways in the vincristine-induced neuropathic pain rat model by bioinformatics analysis. Oxycodone could alleviate the vincristine-induced inflammatory signaling in primary microglia and downregulate some DEGs. Further molecular mechanisms need to be explored in the future. PMID: 30881521 [PubMed - in process]
CONCLUSION: Perfusion parameter data acquired from PCT demonstrated predictive value for treatment outcome after palliative chemotherapy, reflected by the significantly higher PS value in the responder group compared with the non-responder group. PMID: 30887741 [PubMed - in process]
CONCLUSION: In clinical routine, a wide variety of treatment approaches is applied, while outcomes in terms of survival are poor. New treatment options are needed for this challenging tumor type. PMID: 30880482 [PubMed - as supplied by publisher]