PRC2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia

This article is protected by copyright. All rights reserved. Schematic representation of the role of Polycomb Repressive Complex 2 (PRC2) on enacting the Wnt/β‐catenin signaling and regulating the homeostasis of intestinal stem cell self‐renewal and differentiation. At transit amplifying (TA) region PRC2 selectively set an epigenomic identity by labelling genes with repressive H3K27me3 mark and therefore enforce and maintain the dichotomy for crypt and villus identities. This manuscript suggest that PRC2 contributes to the stemness instigation process in epithelial hyperplasia in celiac disease and in neoplasia in colorectal carcinoma. Schematic scatter blot on the right demonstrates the genome‐wide change in H3K27me3 occupancy during the differentiation of crypt/Intestinal stem cells to mature enterocytes. Blue dots represents all normalized differential H3K27me3 ChIP‐Seq peaks near protein coding genes of the mouse genome (above genes silenced in crypts and below genes silenced in villi). Red colored triangles denote the genes having significant gene expression difference measured by GRO‐Seq and arrows quantitatively illustrate the gene expression difference in enterocytes relative to crypts/ISCs (up=activation, down=repression).
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research