In Klinefelter Syndrome Patients, What are the Common Behavioral Problems?
Discussion Klinefelter syndrome (KS) is a common genetic abnormaly with a prevalence of 1 in ~650 male births. It was first described in 1942 by Dr. Harry Klinefelter. It is associated with at least one extra X chromosome with the most common karyotype (~80% of patients) being 47 XXY. Other karyotypes are seen along with mosaicism. It is believed that although it is very prevalent, only about 25-33% of people with KS are identified. About 10% are identified before puberty with the rest usually identified because of hypogonadism and tall stature especially in teenage years or due to infertility in adulthood. KS is diagnosed by karyotype. The phenotype varies but most commonly is associated with hypogonadotropic hypogonadism, infertility, gynecomastia and tall stature. The tall stature is remarkable for a lower segment> upper segment body habitus which can be noted after age 5 years. It is felt that the SHOX gene located on the X chromosome may play a part in this growth pattern. KS patients have underdeveloped genitalia with small phallus and small testes (or cryptochidism). The testes have changes from fetal life but the testes start to enlarge at the time of puberty and then rapidly undergo fibrosis particularly of the Sertoli cells. Patients have elevated follicle-stimulating hormone and luteinizing hormone, but decreased testosterone. Decreased androgen can lead to decreased body hair or muscle strength and treatment with testosterone is usually given in adolescence if...
Conclusion: Proteins and nucleic acids in uEVs represent promising biomarker for the diagnosis and treatment of DKD. PMID: 29786051 [PubMed - in process]
Conclusion: Intestinal F. nucleatum is a valuable marker for CRC diagnosis. PMID: 29786050 [PubMed - in process]
Conclusion: This study developed and validated a model including demographic and clinical indices to evaluate the probability of presenting proliferative LN to guide therapeutic decisions and outcomes. PMID: 29786038 [PubMed - in process]
Conclusion: With preoperative chemoradiotherapy, individualized APE may be a relatively safe and feasible approach for low rectal cancer with acceptable oncological outcomes. PMID: 29786037 [PubMed - in process]
Abstract Background: Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological parameters best predict the outcomes of single blastocyst transfer. In addition, most of the previous studies did not exclude the effect of embryo aneuploidy on blastocysts transfer. Thus, the present study investigated the predictive value of various parameters on the pregnancy outcomes achieved via the transfer of frozen euploid blastocysts. Methods: The study retrospectively analyzed 914 single euploid b...
Public Health England -This guidance outlines how to optimise the NHS Diabetes Prevention Programme in order to identify those already found to be at risk of developing Type 2 diabetes and offer support that will help them reduce their risk of developing the disease.GuidancePublic Health England - publications
CONCLUSION: Treatment with ESL could improve some aspects of theory of mind in patients with epilepsy, especially in men and independently of the control of seizures, with no changes in quality of life, anxiety or depression. PMID: 29790568 [PubMed - in process]
While has hasn ’t been in the news quite as often as his namesake, Dr. Donald “Skip” Trump is celebrating a record-setting fundraising event to benefit a cancer center in Virginia.
For some, symptoms of autism can hamper their daily lives, but drugs to mitigate these have floundered during trials. Shafali Jeste has an idea of why
Cancer quacks frequently characterize conventional treatments for cancer as "cutting, poisoning, and burning." Yet, in Australia a woman with ovarian cancer chose black salve, in essence, "cutting, poisoning, and burning" (but mostly burning and without the cutting) to treat her disease. She died a horrible death. How can black salve still be a thing. The post Helen Lawson and black salve: Cutting, burning, and poisoning “naturally” appeared first on RESPECTFUL INSOLENCE.
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