Prevalence and genotype distribution of methicillin-resistant Staphylococcus aureus (MRSA) in India

Publication date: Available online 28 August 2016 Source:Journal of Global Antimicrobial Resistance Author(s): Raju Sunagar, Nagendra Ramachandra Hegde, Ganapuram Jagadishwar Archana, Akhauri Yash Sinha, Kammili Nagamani, Shrikrishna Isloor Methicillin-resistant Staphylococcus aureus (MRSA) is a serious human pathogen that can cause a wide variety of infections. Comparative genetic analyses have led to the discovery that despite the existence of a vast number of genotypes, outbreak strains of MRSA appear to be limited to certain genotypes, some of which are further restricted to certain geographical locations. Whereas extensive literature is available in several countries, the complexity of the clonal distribution both of healthcare-associated (HA) and community-associated (CA) MRSA in India is only now beginning to be understood. Studies have revealed that MRSA in India is distributed among all of the major staphylococcal cassette chromosome mec (SCCmec) types. The majority of HA-MRSA isolates belong to SCCmec type III and sequence type (ST) 239. By contrast, CA-MRSA mostly belong to ST22 (SCCmec IV), ST772 (SCCmec V) and ST672 (SCCmec V) genotypes. Similar to the global scenario, CA-MRSA is becoming more invasive and transmissible and is increasingly becoming difficult to be differentiated from HA-MRSA. In addition, it is disturbing that some of the HA-MRSA isolates have been reported to be vancomycin-resistant. On the other hand, almost no information is available on the ...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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CONCLUSION: the reuse of the enzymatic detergent solution is a risk to the safe processing of endoscopic devices, evidenced by its contamination with pathogenic potential microorganisms, since the enzymatic detergent has no bactericidal property and can contribute as an important source for outbreaks in patients under such procedures. PMID: 31826156 [PubMed - in process]
Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
Condition:   Antibiotic Reaction Intervention:   Diagnostic Test: urine culture Sponsor:   Batool Mutar Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: We present the most detailed genomic analysis of MRSA isolated in Sri Lanka to date. The analysis identified a PVL-positive ST5-MRSA-IVc that is prevalent among MRSA causing clinical infections in Sri Lanka. Furthermore, this clone was also found among isolates from the United Kingdom and Australia. Introduction Worldwide, Staphylococcus aureus is the primary causative agent of community-acquired skin and soft tissue infections (SSTI) and is an important cause of hospital-associated invasive infections including bacteremia, pneumonia and endocarditis (Bell et al., 2002; David and Daum, 2010). Panton-Va...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
ConclusionsWe demonstrate the potential utility of combined epidemiological and genomic MRSA BSI surveillance to determine the national population structure of MRSA, contextualise previous MRSA outbreaks, and detect potentially high-risk lineages. These findings support the integration of epidemiological and genomic surveillance for MRSA BSI as a step towards a comprehensive surveillance programme in England. PMID: 30696529 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is a major cause of severe healthcare‐associated (HA) infections. Although during the last decade the incidence of HA invasive infections has dropped, the incidence of community‐associated MRSA (CA‐MRSA) infections has risen among the general population. Moreover, CA‐MRSA, livestock‐associated MRSA (LA‐MRSA) and HA‐MRSA (HA‐MRSA) can be found in foods intended for human consumption. Several studies from different geographical areas have reported the presence of enterotoxin genes in several MRSA food isolates. Molecular typing studies have reveale...
Source: Letters in Applied Microbiology - Category: Microbiology Authors: Tags: Review Article Source Type: research
ConclusionsBased on our model, MRSA elimination from nursing homes, while theoretically possible, was unlikely to be achieved in practice. Decolonization therapy that can sustain higher clearance rates or lower MRSA-positive introductions over years may reduce strain-specific prevalence of MRSA in the facilities, and antibiotic stewardship may contribute to this effort. Large-scale MRSA outbreaks were unlikely in this setting.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
Publication date: Available online 17 May 2016 Source:Journal of Global Antimicrobial Resistance Author(s): A.M. Bal, G.W. Coombs, M.T.G. Holden, J.A. Lindsay, G.R. Nimmo, P. Tattevin, R.L. Skov The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, wit...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
The correct interpretation of microbial sequencing data applied to surveillance and outbreak investigation depends on accessible genomic databases to provide vital genetic context. Our aim was to construct and describe a United Kingdom MRSA database containing over 1000 methicillin-resistant Staphylococcus aureus (MRSA) genomes drawn from England, Northern Ireland, Wales, Scotland, and the Republic of Ireland over a decade. We sequenced 1013 MRSA submitted to the British Society for Antimicrobial Chemotherapy by 46 laboratories between 2001 and 2010. Each isolate was assigned to a regional healthcare referral network in En...
Source: Genome Research - Category: Genetics & Stem Cells Authors: Tags: RESOURCES Source Type: research
Carrie Arnold is a freelance science writer living in Virginia. Her work has appeared in Scientific American, Discover, New Scientist, Smithsonian, and more. Background image: Reprinted by permission from Macmillan Publishers Ltd: doi:10.5923/s.microbiology.201401.02 About This Article open Citation: Arnold C. 2015. Outbreak breakthrough: using whole-genome sequencing to control hospital infection. Environ Health Perspect 123:A281–A286; http://dx.doi.org/10.1289/ehp.123-A281 Published: 1 November 2015 PDF Version (2.7 MB) The level of detail provided by whole-genome sequencing could give hospita...
Source: EHP Research - Category: Environmental Health Authors: Tags: Featured Focus News November 2015 Source Type: research
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