Prevalence and genotype distribution of methicillin-resistant Staphylococcus aureus (MRSA) in India

Publication date: Available online 28 August 2016 Source:Journal of Global Antimicrobial Resistance Author(s): Raju Sunagar, Nagendra Ramachandra Hegde, Ganapuram Jagadishwar Archana, Akhauri Yash Sinha, Kammili Nagamani, Shrikrishna Isloor Methicillin-resistant Staphylococcus aureus (MRSA) is a serious human pathogen that can cause a wide variety of infections. Comparative genetic analyses have led to the discovery that despite the existence of a vast number of genotypes, outbreak strains of MRSA appear to be limited to certain genotypes, some of which are further restricted to certain geographical locations. Whereas extensive literature is available in several countries, the complexity of the clonal distribution both of healthcare-associated (HA) and community-associated (CA) MRSA in India is only now beginning to be understood. Studies have revealed that MRSA in India is distributed among all of the major staphylococcal cassette chromosome mec (SCCmec) types. The majority of HA-MRSA isolates belong to SCCmec type III and sequence type (ST) 239. By contrast, CA-MRSA mostly belong to ST22 (SCCmec IV), ST772 (SCCmec V) and ST672 (SCCmec V) genotypes. Similar to the global scenario, CA-MRSA is becoming more invasive and transmissible and is increasingly becoming difficult to be differentiated from HA-MRSA. In addition, it is disturbing that some of the HA-MRSA isolates have been reported to be vancomycin-resistant. On the other hand, almost no information is available ...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research