Impact of prenatal and postnatal exposure to bisphenol A on female rats in a two generational study: Genotoxic and immunohistochemical implications

Publication date: Available online 28 August 2016 Source:Toxicology Reports Author(s): Gihan G. Moustafa, Amal A.M. Ahmed Environmental xenoestrogen contaminant bisphenol A (BPA), widely used as a monomer in the manufacture of epoxy, polycarbonate plastics and polystyrene resins. However, exposure to BPA has raised concerns, and the negative impacts of its exposure on reproduction have been controversial. The purpose of this work was directed to assess the potential adverse effects of BPA on dam rats and their first generation females in a comparative toxicological study. Fifteen pregnant female rats were classified into three equal groups; first group was orally administered corn oil and served as control (group1), second and third groups were orally administered BPA at dose levels of 50 and 200mg/kg b.wt respectively (groups 2 & 3). The administration was carried out daily from zero day through the gestation period (21days) until the last day of the lactation period (21days) and was extended after weaning for three months, in which female off springs of first generation (F1) of the three groups of dams were classified into; F1control group (group 4), F1 group treated with low dose of BPA (group 5) and F1 group treated with high dose of BPA (group 6) which continued in daily oral administration of BPA at the same previously mentioned doses for three months. The results elucidated a clear marked DNA fragmentation in the ovary of both dam and F1 female groups especially a...
Source: Toxicology Reports - Category: Toxicology Source Type: research

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Publication date: Available online 17 September 2019Source: Molecular and Cellular EndocrinologyAuthor(s): C. Fraichard, F. Bonnet, A. Garnier, M. Hébert-Schuster, A. Bouzerara, P. Gerbaud, I. Ferecatu, T. Fournier, I. Hernandez, S. Trabado, J. GuibourdencheAbstractPlacental syncytiotrophoblast (ST) is considered as the main placental endocrine tissue secreting progesterone, a steroid essential for maintenance of pregnancy. However, each step of progestins production has been poorly investigated in villous cytotrophoblast (VCT) regarding ST formation. We aimed to characterize progestins production during human diffe...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Associations disappear by end of primary school, and might not be causal, but caution advised Related items fromOnMedica Monthly testing with isotretinoin might be unnecessary NSAIDs and COX 2s linked to heart failure admission US expert group updates statins recommendations Educate teens about cannabis mental health risks Debate goes on over valproate in pregnancy
Source: OnMedica Latest News - Category: UK Health Source Type: news
This study aimed to investigate the effects of dexamethasone on fetal cholesterol levels, and explore its placental mechanism. Pregnant Wistar rats were injected subcutaneously with dexamethasone (0.8 mg/kg·d) from gestational day 9 to 20. Results showed that dexamethasone increased maternal serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) levels, as well as placental cholesterol synthesis and TC concentration, while reduced fetal birth weight, and serum TC, HDL-C and LDL-C levels. Meanwhile, the expression of placental cholesterol transporters...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
This study demonstrates a critical timing of cigarette smoke exposure over the life-course for establishing persistent changes in DNA methylation into adolescence in a dose dependent manner. There were significant associations between offspring CpG methylation and adolescent cardiovascular risk factors, namely TG, HDL-C and diastolic blood pressure. Future studies on current smoking habits and DNA methylation should consider the importance of maternal smoking during pregnancy and explore how the persistent DNA methylation effects of in utero smoke exposure increase cardiometabolic risk.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsHigher inflammatory potential of the diet was positively associated with higher total cholesterol levels in women with SLE. These findings suggest that the inflammatory potential of a person’s diet may play a role in lipid profiles in this population. Future intervention studies are needed to build on these results and explore the effect of anti-inflammatory diets on health outcomes in individuals with SLE.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
The objective of this study was to evaluate the effects of supplementing essential fatty acids (FA), during late gestation and the preweaning and early weaning periods on passive immunity, growth, health, rumen fermentation parameters, blood metabolites, and behavior of dairy calves. During the last 3 weeks of pregnancy, cattle (n = 120), within parity, were randomly assigned to 1 of 3 diets (DD) with different fat supplements, no supplemental fat (CON), supplement rich in C18:2n-6 (CSO), or supplement rich in eicosapentaenoic and docosahexaenoic acid (CFO). Eighty-four newborn Holstein calves were randomly assigned, withi...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.MethodsCoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n = 23) and in those complicated with ICP (n = 13), were investigated.ResultsA significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105 ± 0.010 vs. 0.069 ± 0.011, P 
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 16 July 2019Source: Reproductive ToxicologyAuthor(s): Barbara A. Cohn, Michele A. La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. CirilloAbstractWe tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 1...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Publication date: Available online 16 August 2019Source: Reproductive ToxicologyAuthor(s): Debbie Yancu, Thomas SandersonAbstractWe determined whether 5 common essential oils (basil, fennel seed, orange, black pepper and sage) interfered with feto-placental steroidogenesis in a co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells. After a 24 h exposure, only basil and fennel seed oil significantly increased hormone concentrations of estradiol, estrone, dehydroepiandrosterone (DHEA), androstenedione, progesterone, and estriol. Basil and fennel seed oil were shown ...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
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