Mom of overdose victim blames drug policy
In March, Louise Vincent was forced to live every parent's worst nightmare. Her daughter Selena died after a drug overdose. She was 19. Yet despite Vincent's grief, it's not heroin that she blames for Selena's death. "Drug policy is really what's killi...
In Sketchy they say Sodium Bicarbonate is used to treat TCA overdose. One of the reasons they say is because it increases serum pH which favors the non-ionized form of the drug. Why is this? I thought increase serum pH> less H+. Then to compensate for this decrease in H+, wouldn't TCA ionize more to replace to lost H+ ions?
ConclusionsWhole-body physiologically based pharmacokinetic models of metformin and cimetidine were built and qualified for the prediction of metformin pharmacokinetics during drug –gene interaction, drug–drug interaction, and different stages of renal disease. The model files will be freely available in the Open Systems Pharmacology model repository. Current guidelines for metformin treatment of renally impaired patients should be reviewed to avoid overdosing in CKD3 and to allow metformin therapy of CKD4 patients.
BACKGROUND: Since 2010, heroin-related overdoses have risen sharply, coinciding with policies to restrict access to prescription opioids. It is unknown if patients tapered or discontinued off prescription opioids transitioned to riskier heroin use. This st...
Conclusion: Fentanyl preference is highly prevalent among rural PWID in WV and associated with factors that may exacerbate overdose risks. There is an urgent need for increased access to tailored harm reduction services that address risks associated with fentanyl preference. PMID: 32441202 [PubMed - as supplied by publisher]
Each year in the United States, approximately half a million reproductive-aged women are afflicted with major depression. Pregnant and postpartum women can be reluctant to openly disclose their suffering related to depression and other stigmatizing illnesses (eg, mood and anxiety disorders, posttraumatic stress disorder, and substance use disorders) and subsequently remain symptomatic with no relief. Maternal mortality related to these conditions is significant, with maternal suicide and overdose-related death peaking between 7 and 12 months postpartum. Geographic challenges in accessing perinatal mental health experts can...
Conclusion There was strong agreement by participants on what should be considered core competencies for Australian pharmacists in opioid supply. Given the large number of items identified, further research may help determine priorities for training and education.
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More than 151,000 Americans died from drug overdoses, alcohol and suicide combined in 2018, slightly lower than the overall numbers in 2017, and leveling off for the first time in two decades, according to a new study.