Inter-organ handling of Fibroblast Growth Factor-23 in humans.

Inter-organ handling of Fibroblast Growth Factor-23 in humans. Am J Physiol Renal Physiol. 2016 Aug 24;:ajprenal.00396.2016 Authors: Verzola D, Ansaldo F, Milanesi S, Parodi EL, Rosa GM, Sofia A, Bonanni A, Viazzi F, Balbi M, Garibotto G Abstract Fibroblast Growth Factor-23 (FGF-23) accumulates in blood of patients with chronic kidney disease (CKD) and is associated both with cardiovascular complications and disease progression. However, our knowledge of the sites and mechanisms which regulate plasma FGF-23 is still incomplete. We measured plasma intact FGF-23 across the kidney, splanchnic organs and lung in eleven patients (eGFR 60 ± 6 ml/min) during elective diagnostic cardiac catheterizations. In these patients FGF-23 was removed by the kidney, with a fractional extraction (FE) of ~22%. The FE of FGF-23 across the kidney was similar to that of creatinine (~17 %, p=NS). In addition, the FGF-23 FE by the kidney was significantly directly related to eGFR (r = 0.709 p = 0.018) and to kidney creatinine FE (r=0.736 p=0.013) but only as a trend, to plasma phosphate levels (r=0.55, p=0.18). There was no difference in FGF-23 levels in blood perfusing splanchnic organs and cardiopulmonary bed. However, the arterial-venous difference of FGF-23 across the lung was directly related to FGF-23 pulmonary artery levels, suggesting that the lung, and possibly the heart, participate in the homeostasis of plasma FGF-23 when its systemic levels are i...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research