The Power Of The Gut

As an integrative medicine physician, I stay current with scientific research relevant to patient health in my clinical practice. Over the past two decades, I began seeing an increasing incidence of hormonal and immune dysregulations in my patients. Also, autoimmune diseases, depression, anxiety, and obesity began showing up in unprecedented numbers. A few years ago, I became aware of the ongoing research on the human gut microbiome. Much of the published researched explained what I was seeing in my clinical practice as linked to a disrupted gut biome. As I began applying the recommended protocols to healing the microbiome of my patients, I was amazed at the clinical improvements I witnessed in a relatively short time, both in symptoms and blood levels associated with inflammation, autoimmune disease, joint pain, chronic skin conditions, depression, anxiety, bowel disorders, chronic fatigue, fibromyalgia, and even viral infections as well as a significant decrease in the incidence of the flu during 'flu season'. Understanding the gut microbiome is a very important and interesting subject. I emphasize that my patients learn about it, in addition to support it through diet, lifestyle, and correct probiotics. Over the past two decades, the body of research showing a causal relationship between a healthy gut microbiome and disease expression and reversal is vast. The information is so critical I feel it important to describe in detail in this article, so people can make consc...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Source: Clinics in Perinatology - Category: Perinatology & Neonatology Source Type: research
The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. Disruptions to the DA system are implicated in a number of neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and, more recently, autism spectrum disorder (ASD). An ASD-associated de novo mutation in the SLC6A3 gene resulting in a threonine-to-methionine substitution at site 356 (DAT T356M) was recently identified and has been show...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Irreversible T cell exhaustion limits the efficacy of programmed cell death 1 (PD-1) blockade. We observed that dual CD40-TLR4 stimulation within a single tumor restored PD-1 sensitivity and that this regimen triggered a systemic tumor-specific CD8+ T cell response. This approach effectively treated established tumors in diverse syngeneic cancer models, and the systemic effect was dependent on the injected tumor, indicating that treated tumors were converted into necessary components of this therapy. Strikingly, this approach was associated with the absence of exhausted PD-1hi T cells in treated and distant tumors, while s...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Although modifications of gut microbiota with antibiotics (Abx) influence mouse skin and cardiac allografts, its role in orthotopic liver transplantation (OLT) remains unknown. We aimed to determine whether and how recipient Abx pretreatment may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. Mice (C57BL/6) with or without Abx treatment (10 days) were transplanted with allogeneic (BALB/c) cold-stored (18 hours) livers, followed by liver and blood sampling (6 hours). We divided 264 human OLT recipients on the basis of duration of pre-OLT Abx treatment into control (Abx-free/Abx
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Organ transplantation is now a preferred treatment for end-stage organ failure. Among the challenges for ensuring excellent clinical outcomes for transplant recipients is good initial allograft function at the time of organ implantation. This is determined in part by the functional status of the donor and donor organ, functional status of the recipient, and conduct of the operative procedure. Despite optimization of these variables, organ transplantation is still often plagued by substantial initial dysfunction, variably referred to as slow or delayed graft function, or in the most extreme cases, primary graft nonfunction ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Skin and intestinal epithelial barriers play a pivotal role in protecting underlying tissues from harsh external environments. The protective role of these epithelia is, in part, dependent on a remarkable capacity to restore barrier function and tissue homeostasis after injury. In response to damage, epithelial wounds repair by a series of events that integrate epithelial responses with those of resident and infiltrating immune cells including neutrophils and monocytes/macrophages. Compromise of this complex interplay predisposes to development of chronic nonhealing wounds, contributing to morbidity and mortality of many d...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1) loss-of-function mutations are characterized by cardiolipin accumulation, a mitochondrial-specific phospholipid. Suppression of ABCA1 expression occurs in glomeruli from patients with diabetic kidney disease (DKD) and in human podocytes exposed to DKD sera collected prior to the development of DKD. We demonstrated that siRNA ABCA1 knockdown in podocytes led to reduced oxygen consumption capabilities associated with alterations in the oxidative phosphorylation (OXPHOS) complexes and with cardiolipin accumulation. Podocyte-specific deleti...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
pidemiologists focus on possible health effects of synthetic compounds known as 'forever chemicals' More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298915&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Active surveillance (AS) has been widely accepted as a first-line management approach in men with low-risk prostate cancer. While AS provides an avenue to reduce risk of overtreatment without compromising oncological safety, there remains a lack of consensus on the optimal approach to monitoring. An ideal surveillance strategy would be one that minimizes invasive testing such as prostate biopsy without conceding adverse oncologic outcomes. Thus, several studies have sought to identify men at higher risk of reclassification so as to more carefully select when biopsy is truly necessary.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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