Andrographolide Pre-treatment Enhances the Anti-tumor Activity of Topotecan on Acute Myeloid Leukemia Cells In Vitro

Topotecan (TP) is an anticancer drug currently being used in the treatment of several cancer types including leukemia. However, due to its dose-limiting cytotoxicity, combination treatments have been investigated to achieve better outcome with less side effects. Andrographolide (AG) is a plant-derived compound that was reported to induce apoptosis and autophagy in acute myeloid leukemia cell lines.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research