Identifying the Genomic Landscape of Pediatric Myelodysplastic Syndromes (MDS)

MDS is uncommon in children (incidence of ∼2 cases/million) and carries a poor prognosis. Much has been learned about adult MDS using high-throughput sequencing, which has identified recurrent mutations in genes that regulate epigenetics and RNA transcript splicing. Much less is understood about pediatric MDS, and many recurrent mutations found in adults are not common in children. Furthermore, the clinical presentation, bone marrow morphology, and cytogenetic abnormalities are also different when comparing adult and pediatric MDS, suggesting disparate underlying mechanisms.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Myelodysplastic Syndromes Source Type: research