BRAF and MAP2K1 Genes Mutation in Splenic Marginal Zone Lymphoma and Hairy Cell Leukemia

Splenic marginal zone lymphoma (SMZL), a specific type of small B-cell lymphoma. Hairy cell leukemia (HCL) has characteristics to distinguish it from other B-cell lymphomas. Sequencing revealed that mutation in BRAF gene detected in 100% of patients HCL and demonstrate constitutive activation of RAF-MEK-ERK-cascade. These findings make a significant contribution to the diagnosis of issues and allow distinguishing HCL from similar B-cell lymphomas, such as SMZL.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research