The Simultaneous Blockade of mTOR and Nuclear Transporter Exportin-1 Induces Synergistic Antitumor Effect through Pro-Survival Metabolism in Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma with poor prognosis, characterized by aberrant expression of growth-regulating and oncogenic effectors. Novel therapeutic approaches are warranted for improved anti-tumor activity.

Source: Clinical Lymphoma, Myeloma and Leukemia - August 26, 2016 Category: Hematology Authors: Kazumasa Sekihara, Kaori Saitoh, Takashi Miida, Michael Andreeff, Marina Konopleva, Yoko Tabe Tags: Research Topics Source Type: research