TNF- α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

High fat diet (HFD) induces insulin resistance in various tissues, including the vasculature. HFD also increases plasma levels of TNF- α, a cytokine that contributes to insulin resistance and vascular dysfuncti...

http://cardiab.biomedcentral.com/articles/10.1186/s12933-016-0443-0

Source: Cardiovascular Diabetology - August 25, 2016 Category: Cardiology Authors: Rafael Menezes da Costa, Karla Bianca Neves, Fab íola Leslie Mestriner, Paulo Louzada-Junior, Thiago Bruder-Nascimento and Rita C. Tostes Source Type: research