Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands.

Near-infrared luminescence and RNA cleavage ability of lanthanide Schiff base complexes derived from N,N'-bis(3-methoxysalicylidene)ethylene-1,2-diamine ligands. J Inorg Biochem. 2016 Aug 5; Authors: Kaczmarek AM, Porebski PW, Mortier T, Lynen F, Van Deun R, Van Hecke K Abstract A complete series of lanthanide Schiff base salen-type complexes were prepared with trivalent lanthanide ions (Ln(3+)) and the N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine ligand (Ln(3+)=La(3+), Ce(3+), Pr(3+), Nd(3+), Sm(3+), Eu(3+), Gd(3+), Tb(3+), Dy(3+), Ho(3+), Er(3+), Tm(3+), Yb(3+), Lu(3+)). Three unique crystal structures of La(3+) and Pr(3+)N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine complexes, with the La(3+) complex prepared in two different synthetic approaches, are reported, namely a dimeric [La(H2L)(NO3)3]2 (H2L=N,N'-bis-(3-methoxysalicylidene)ethylene-1,2-diamine) complex, an asymmetric two-centered [La2(H2L)2(NO3)6] complex and a discrete mononuclear [Pr(H2L)(NO3)2(H2O)2] complex. For Nd(3+) and Sm(3+), an isotypic mononuclear [Nd(H2L)(NO3)3] and 1D polymeric [Sm(H2L)(NO3)3(MeOH)]n structure was obtained, respectively. The whole series of complexes was tested for their ability to cleave the 20-mer RNA oligonucleotide 5'-AGC-GAU-AAG-AUU-CAU-AUA-UC-3'. Additionally three complexes (Ln(3+)=Nd(3+), Sm(3+), Ho(3+)) were tested for the cleavage of the 12-mer RNA oligonucleotide 5'-GCA-CCC-UGU-CAG-3'. A detailed luminescence study wa...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research
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